SYNTHESIS AND CYTOTOXICITY PROPERTIES OF SOME NOVEL FUNCTIONALIZED 2-{2-[(4-OXO-4H-CHROMEN-3-YL)-METHYLENE]-HYDRAZINYL}-1,3-SELENAZOLES

被引：4

作者：

Ali, Tarik E. ^{[1
,2
]}

Assiri, Mohammed A. ^{[1
]}

Aboelwafa, Hanaa R. ^{[3
]}

机构：

[1] King Khalid Univ, Fac Sci, Dept Chem, Abha, Saudi Arabia

[2] Ain Shams Univ, Fac Educ, Dept Chem, Cairo, Egypt

[3] Ain Shams Univ, Fac Educ, Dept Biol & Geol, Cairo, Egypt

来源：

HETEROCYCLES | 2021年 / 102卷 / 05期

关键词：

BIOLOGICAL EVALUATION; CHROMONES; DERIVATIVES; SELENIUM;

D O I：

10.3987/COM-21-14424

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel functionalized 1,3-selenazoles bearing 4-oxo-4H-chromen-3-yl moiety was constructed by Hantzsch-type condensation reaction. The methodology depended on the cyclization of N-[(4-oxo-4H-chromen- 3-yl)methylene]selenosemicarbazide with bis-halogen and alpha-halocarbonyl compounds in DMF. The structures of the synthesized compounds were assigned based on the spectral tools. The cytotoxicity properties of the products were evaluated. Both compounds 9 and 11 showed significant cytotoxic properties against HCT-116, Hep-G2, A-549 and MCF-7 cancer cell lines.

引用

页码：920 / 929

页数：10

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