A kinetic view of clathrin assembly and endocytic cargo sorting

被引:12
作者
Wu, Min [1 ]
Wu, Xudong [2 ,3 ]
机构
[1] Yale Univ, Sch Med, Dept Cell Biol, 333 Cedar St, New Haven, CT 06520 USA
[2] Harvard Med Sch, Howard Hughes Med Inst, 240 Longwood Ave, Boston, MA 02115 USA
[3] Harvard Med Sch, Dept Cell Biol, 240 Longwood Ave, Boston, MA 02115 USA
关键词
Endocytosis; Knetic proofreading; Hsc70; Cargo sorting; VESICLE FORMATION; COATED PIT; GTP HYDROLYSIS; AUXILIN; MECHANISM; POLYMERIZATION; RECONSTITUTION; VISUALIZATION; RECRUITMENT; DEPLETION;
D O I
10.1016/j.ceb.2021.02.010
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Specificity and sensitivity in biochemical reactions can be achieved through regulation of equilibrium binding affinity or through proofreading mechanisms that allow for the dissociation of unwanted intermediates. In this essay, we aim to provide our perspectives on how the concept of kinetic proofreading might apply in the context of cargo sorting in clathrin-mediated endocytosis.
引用
收藏
页码:130 / 138
页数:9
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