The effect of protease inhibitors-based antiretroviral therapy on serum/plasma interleukin-6 levels among PLHIV: a systematic review and meta-analysis

被引:0
作者
Ashuro, Akililu Alemu [1 ,2 ]
Zhang, Si-Chen [1 ,2 ]
Wang, Ting [1 ,2 ]
Chu, Qin-Shu [1 ,2 ]
Fu, Yuan-Sheng [1 ,2 ]
Fan, Yin-Guang [1 ,2 ]
Ye, Dong-Qing [1 ,2 ]
机构
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Anhui Prov Key Lab Major Autoimmune Dis, Hefei 230032, Anhui, Peoples R China
关键词
antiretroviral therapy; HIV; inflammation; serum; plasma IL-6 levels; GENITAL-TRACT INFLAMMATION; HIV-INFECTION; IMMUNE ACTIVATION; INSULIN-RESISTANCE; MICROBIAL TRANSLOCATION; HYALURONIC-ACID; ADIPOSE-TISSUE; IL-6; LEVELS; CELL COUNT; PLASMA;
D O I
10.1002/jmv.27912
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Recommended treatment regimen for human immune deficiency virus (HIV) infection includes protease inhibitors/ritonavir (PIs/r) combined with two-nucleoside reverse-transcriptase inhibitors (2NRTIs), which enable to achieve and maintain viral suppression, restore, and preserve immune function. However, there were inconsistent findings on the levels of interleukin-6 (IL-6) levels. Systematic review and meta-analysis were performed to quantify the pooled effects of PIs/r-based antiretroviral therapy (ART) on serum/plasma IL-6 levels in people living with the HIV (PLHIV). PubMed, Web of Science, and Embase were searched from the earliest record to November 4, 2020. Data analysis was conducted on Stata version 16 and Review Manager 5.3. A random-effect model was used to compute a pooled effect size and weighted mean difference (WMD) was considered the summary effect size. Heterogeneity between studies was estimated by Cochrane's Q test (chi(2) test) and I-2 statistic and subgroup analysis were performed to explore the source of heterogeneity. Initial search identified 3098 records and 5 studies (7 trials) met inclusion criteria. The pooled mean difference in serum/plasma IL-6 levels from baseline to follow-up was 0.534 pg/ml (95% confidence interval: -0.012, 1.08, P = 0.05, I-2 = 76.4%). In subgroup analysis, there was a significant association between increased serum/plasma IL-6 levels and age group >= 35 years old, baseline CD4(+) counts < 350 cell/mm(3), and mean viral load >= 4.5 log10 copies/ml. We found that serum/plasma IL-6 levels increased after combined ART among treatment-naive individuals who initiated a successful combination of PIs/r with 2NRTIs. This result also highlights the need to monitor serum/plasma IL-6 levels during antiviral therapy, which may aid in the effective future treatment of systemic inflammation and related disorders following elevated IL-6 levels.
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收藏
页码:4669 / 4676
页数:8
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