Supportive Management of Patients with Advanced Pheochromocytomas and Paragangliomas Receiving PRRT

被引：5

作者：

Tsang, Erica S. ^{[1
]}

Funk, Gayle ^{[2
]}

Leung, Janet ^{[2
]}

Kalish, Grace ^{[2
]}

Kennecke, Hagen F. ^{[3
,4
]}

机构：

[1] BC Canc, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada

[2] Virginia Mason Canc Inst, Seattle, WA 98101 USA

[3] Providence Canc Inst, Portland, OR 97213 USA

[4] Chiles Res Inst, Portland, OR 97213 USA

来源：

CURRENT ONCOLOGY | 2021年 / 28卷 / 04期

关键词：

pheochromocytoma; paraganglioma; peptide receptor radionuclide therapy; RECEPTOR RADIONUCLIDE THERAPY; CONSENSUS GUIDELINES; LU-177-DOTATATE; CRISES; TRIAL;

D O I：

10.3390/curroncol28040247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peptide receptor radionuclide therapy (PRRT) is used to treat patients with advanced malignant pheochromocytomas (PCCs) and paragangliomas (PGLs). Patients are at risk of a PRRT-induced catecholamine crisis, and standard guidelines regarding the prevention and management of infusion reactions are lacking. In this case series, the institutional experience of five sequential patients with metastatic PCCs and PGLs receiving PRRT on an outpatient basis is described, of which four had symptomatic tumors and three had a high burden of disease. All patients with symptomatic tumors were treated with preventive management prior to the initiation of PRRT, and no infusion reactions or catecholamine crises were documented. PRRT may be delivered safely on an outpatient basis for patients with metastatic PCCs and PGLs with the involvement of an interdisciplinary team.

引用

页码：2823 / 2829

页数：7

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