Ferrihydrite nanoparticles interaction with model lipid membranes

被引：11

作者：

Chilom, Claudia G. ^{[1
]}

Zorila, Bogdan ^{[2
]}

Bacalum, Mihaela ^{[2
]}

Balasoiu, Maria ^{[3
,4
,5
]}

Yaroslavtsev, Roman ^{[6
,7
]}

Stolyar, Sergey, V ^{[6
,7
]}

Tyutyunnicov, Sergey ^{[4
]}

机构：

[1] Univ Bucharest, Fac Phys, Dept Elect Solid State & Biophys, Magurele, Romania

[2] Horia Hulubei Natl Inst Phys & Nucl Engn, Dept Life & Environm Phys, Reactorului 30, Magurele 077125, Romania

[3] Horia Hulubei Natl Inst Phys & Nucl Engn, Dept Nucl Phys, Magurele, Romania

[4] Joint Inst Nucl Res, Dubna, Russia

[5] Moscow Inst Phys & Technol, Dolgoprudnyi, Russia

[6] Siberian Fed Univ, Krasnoyarsk, Russia

[7] SB RAS, Kirensky Inst Phys, Krasnoyarsk 660036, Russia

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2020年 / 226卷

关键词：

Ferrihydrite nanoparticles; Morphology; Laurdan; TMA-DPH; Membrane; Fluidity; IRON-OXIDE NANOPARTICLES; FLUORESCENCE-SPECTRA; FLUIDITY; LAURDAN; POLARIZATION; DPH; CYTOTOXICITY; CHOLESTEROL; TOXICITY; BILAYERS;

D O I：

10.1016/j.chemphyslip.2019.104851

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years was observed an increased interest towards the use of metal nanoparticles for various biomedical applications, such as therapeutics, delivery systems or imaging. As biological membranes are the first structures with which the nanoparticles interact, it is necessary to understand better the mechanisms governing these interactions. In the present paper we aim to characterize the effect of three different ferrihydrite nanoparticles (simple or doped with cooper or cobalt) on the fluidity of model lipid membranes. First we evaluated the physicochemical properties of the nanoparticles: size and composition. Secondly, their effect on lipid membranes was also evaluated using Laurdan, TMA-DPH and DPH fluorescence. Our results can help better understand the mechanisms involved in nanoparticles and membrane interactions.

引用

页数：12

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