Altered c-fos expression in autonomic regulatory centers of genetically obese (ob/ob) mouse brain

被引：13

作者：

Huang, XF ^{[1
]}

Wang, HQ ^{[1
]}

机构：

[1] Univ Wollongong, Dept Biomed Sci, Metab Res Ctr, Wollongong, NSW 2522, Australia

来源：

BRAIN RESEARCH | 1998年 / 799卷 / 02期

基金：

英国医学研究理事会;

关键词：

hypothalamus; obesity; food deprivation; neuron;

D O I：

10.1016/S0006-8993(98)00541-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined c-fos-like immunoreactivity (FLI) in the brain of obese (ob/ob) and lean (+/+) mice during states of satiety and hunger. The results demonstrated that there is an altered neural activity primarily in the hypothalamus of the obese mouse brain. Most interestingly, only obese mice had an increased FLI in the dorsomedial and supramammillary nuclei. Conversely, only lean mice showed increase in FLI in the medial part of perifornical nucleus following food deprivation for 24 h. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

引用

页码：307 / 310

页数：4

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