High Prevalence of Clarithromycin Resistance and cagA, vacA, iceA2, and babA2 Genotypes of Helicobacter pylori in Brazilian Children

被引：32

作者：

Garcia, Gabriella T. ^{[1
,2
]}

Aranda, Katia R. S. ^{[1
]}

Goncalves, Manoel E. P.

Cardoso, Silvia R.

Iriya, Kiyoshi ^{[4
]}

Silva, Neusa P. ^{[3
]}

Scaletsky, Isabel C. A. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Inst Crianca, BR-04023062 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Pediat, Inst Crianca, BR-04023062 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Disciplina Reumatol, Inst Crianca, BR-04023062 Sao Paulo, Brazil

[4] Univ Sao Paulo, Fac Med, Dept Patol Med, Sao Paulo, Brazil

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2010年 / 48卷 / 11期

关键词：

23S RIBOSOMAL-RNA; NORTHEASTERN BRAZIL; CLINICAL-RELEVANCE; GENE; INFECTION; IDENTIFICATION; METRONIDAZOLE; MUTATIONS; GASTRITIS; ALLELES;

D O I：

10.1128/JCM.01034-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We isolated 45 Helicobacter pylori strains from 217 child patients. Resistance to clarithromycin, metronidazole, amoxicillin, and tetracycline was detected in 27%, 13%, 4%, and 0% of strains, respectively. The A2143G mutation was the most prevalent (67%) among clarithromycin-resistant strains. In addition, strain genotyping revealed a significant association between gastritis severity and the simultaneous presence of cagA, vacA s1m1, iceA2, and babA2 genes.

引用

页码：4266 / 4268

页数：3

共 29 条

[1] Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori [J].

Atherton, JC ;

Cover, TL ;

Twells, RJ ;

Morales, MR ;

Hawkey, CJ ;

Blaser, MJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (09) :2979-2982

[2] Helicobacter pylori colonization among children up to 6 years:: Results of a community-based study from Northeastern Brazil [J].

Braga, Andrea B. C. ;

Fialho, Andre M. N. ;

Rodrigues, Maria N. ;

Queiroz, Dulciene M. M. ;

Rocha, Andreia M. C. ;

Braga, Lucia L. B. C. .

JOURNAL OF TROPICAL PEDIATRICS, 2007, 53 (06) :393-397

[3]

Broutet N, 2000, HELICOBACTER PYLORI: BASIC MECHANISMS TO CLINICAL CURE 2000, P601

[4]

De Gusmao VR, 2000, J CLIN MICROBIOL, V38, P2853

[5] Classification and grading of gastritis - The updated Sydney System [J].

Dixon, MF ;

Genta, RM ;

Yardley, JH ;

Correa, P ;

Batts, KP ;

Dahms, BB ;

Filipe, MI ;

Haggitt, RC ;

Haot, J ;

Hui, PK ;

Lechago, J ;

Lewin, K ;

Offerhaus, JA ;

Price, AB ;

Riddell, RH ;

Sipponen, P ;

Solcia, E ;

Watanabe, H .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (10) :1161-1181

[6] Primary resistance to clarithromycin in clinical strains of Helicobacter pylori isolated from children in Poland [J].

Dzierzanowska-Fangrat, K ;

Rozynek, E ;

Józwiak, P ;

Celinska-Cedro, D ;

Madalinski, K ;

Dzierzanowska, D .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 18 (04) :387-390

[7] Helicobacter pylori and cagA and vacA gene status in children from Brazil with chronic gastritis [J].

Gatti, LL ;

Agostinho, F ;

de Lábio, R ;

Piason, FB ;

da Silva, LC ;

de Queiroz, VF ;

Peres, CA ;

Barbieri, D ;

Smith, MDC ;

Payao, SLM .

CLINICAL AND EXPERIMENTAL MEDICINE, 2003, 3 (03) :166-172

[8]

Gatti Luciano Lobo, 2006, Braz J Infect Dis, V10, P254, DOI 10.1590/S1413-86702006000400008

[9] Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases [J].

Gatti, Luciano Lobo ;

Proenca Modena, Jose Luiz ;

Marques Payao, Spencer Luiz ;

Cardoso Smith, Marilia de Arruda ;

Fukuhara, Yara ;

Pimenta Modena, Jose Luiz ;

de Oliveira, Ricardo Brandt ;

Brocchi, Marcelo .

ACTA TROPICA, 2006, 100 (03) :232-240

[10] Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin [J].

Gerhard, M ;

Lehn, N ;

Neumayer, N ;

Borén, T ;

Rad, R ;

Schepp, W ;

Miehlke, S ;

Classen, M ;

Prinz, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12778-12783

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