STAT4 Regulates Pathogenic IL-21 and IFN-γ in Tfh Cells in Murine and Human Lupus

被引:0
|
作者
Koumpouras, Fotios [1 ]
Dong, XueMei [2 ]
Weinstein, Jason [2 ]
Craft, Joseph E. [3 ]
机构
[1] Yale Univ, Sch Med, Rheumatol, Internal Med, New Haven, CT USA
[2] Yale Univ, Sch Med, Rheumatol, New Haven, CT USA
[3] Yale Univ, Sch Med, Dept Internal Med Rheumatol, New Haven, CT USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1661
引用
收藏
页数:2
相关论文
共 50 条
  • [1] STAT4 Activation By Type I Interferons Regulates Pathogenic IL-21 and IFN-γ in Lupus
    Dong, Xuemei
    Koumpouras, Fotios
    Craft, Joseph E.
    Weinstein, Jason
    ARTHRITIS & RHEUMATOLOGY, 2018, 70
  • [2] IFN-α regulates IL-21 and IL-21R expression in human NK and T cells
    Strengell, M
    Julkunen, I
    Matikainen, S
    JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (02) : 416 - 422
  • [3] Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-α
    Berenson, Lisa S.
    Gavrieli, Maya
    Farrar, J. David
    Murphy, Theresa L.
    Murphy, Kenneth M.
    JOURNAL OF IMMUNOLOGY, 2006, 177 (08): : 5195 - 5203
  • [4] IFN-α and IL-18 synergistically enhance IFN-γ production in human NK cells:: differential regulation of Stat4 activation and IFN-γ gene expression by IFN-α and IL-12
    Matikainen, S
    Paananen, A
    Miettinen, M
    Kurimoto, M
    Timonen, T
    Julkunen, I
    Sareneva, T
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2001, 31 (07) : 2236 - 2245
  • [5] IFN-α and IL-18 synergistically enhance IFN-γ production in human NK cells:: differential regulation of Stat4 activation and IFN-γ gene expression by IFN-α and IL-12
    Matikainen, S
    Paananen, A
    Miettinen, M
    Lehtonen, A
    Kurimoto, M
    Timonen, T
    Julkunen, I
    Sareneva, T
    JOURNAL OF LEUKOCYTE BIOLOGY, 2001, : 50 - 50
  • [6] Stat4 regulates multiple components of IFN-γ inducing signaling pathways
    Lawless, VA
    Zhang, SM
    Kaplan, MH
    FASEB JOURNAL, 2000, 14 (06): : A1085 - A1085
  • [7] Stat4 regulates multiple components of IFN-γ-inducing signaling pathways
    Lawless, VA
    Zhang, SM
    Ozes, ON
    Bruns, HA
    Oldham, I
    Hoey, T
    Grusby, MJ
    Kaplan, MH
    JOURNAL OF IMMUNOLOGY, 2000, 165 (12): : 6803 - 6808
  • [8] STAT4 Is Required for IFN-β- Induced MCP-1 mRNA Expression in Murine Mast Cells
    Iida, Kazuma
    Suzuki, Kotaro
    Yokota, Masaya
    Nakagomi, Daiki
    Wakashin, Hidefumi
    Iwata, Arifumi
    Kawashima, Hirotoshi
    Takatori, Hiroaki
    Nakajima, Hiroshi
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2011, 155 : 71 - 76
  • [9] IL-12, but not IFN-α, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene
    Persky, ME
    Murphy, KM
    Farrar, JD
    JOURNAL OF IMMUNOLOGY, 2005, 174 (01): : 294 - 301
  • [10] Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells
    Belanger, Simon
    Crotty, Shane
    NATURE IMMUNOLOGY, 2016, 17 (10) : 1135 - 1136