Liver Buds and Liver Organoids: New Tools for Liver Development, Disease and Medical Application

被引：15
作者：
Zeng, Fanhong [1 ]
Zhang, Yue [1 ]
Han, Xu [1 ]
Weng, Jun [1 ]
Gao, Yi [1 ]
机构：
[1] Southern Med Univ, State Key Lab Organ Failure Res, Coinnovat Ctr Organ Failure Res, Dept Hepatobiliary Surg 2,Zhujiang Hosp, 253 Gongye St, Guangzhou 510280, Peoples R China
来源：
STEM CELL REVIEWS AND REPORTS | 2019年 / 15卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Liver buds; Liver organoids; Medical application; MESENCHYMAL STROMAL CELLS; FUNCTIONAL HUMAN LIVER; STEM-CELLS; BONE-MARROW; PRIMARY HEPATOCYTES; HEPATITIS-B; MODEL; CULTURE; MOUSE; EXPANSION;
D O I：
10.1007/s12015-019-09909-z
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The current understanding and effective treatment of liver disease is far from satisfactory. Liver organoids and liver buds (LBs) transforming cell culture from two dimensions(2D) to three dimensions(3D) has provided infinite possibilities for stem cells to use in clinic. Recent technological advances in the 3D culture have shown the potentiality of liver organoids and LBs as the promising tool to model in vitro liver diseases. The induced LBs and liver organoids provide a platform for cell-based therapy, liver disease models, liver organogenesis and drugs screening. And its genetic heterogeneity supplies a way for the realization of precision medicine.
引用
收藏
页码：774 / 784
页数：11
相关论文
共 107 条
[1]   Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential [J].
Al-Nbaheen, May ;
Vishnubalaji, Radhakrishnan ;
Ali, Dalia ;
Bouslimi, Amel ;
Al-Jassir, Fawzi ;
Megges, Matthias ;
Prigione, Alessandro ;
Adjaye, James ;
Kassem, Moustapha ;
Aldahmash, Abdullah .
STEM CELL REVIEWS AND REPORTS, 2013, 9 (01) :32-43
[2]   Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations [J].
Andersson, Emma R. ;
Chivukula, Indira V. ;
Hankeova, Simona ;
Sjoqvist, Marika ;
Tsoi, Yat Long ;
Ramskold, Daniel ;
Masek, Jan ;
Elmansuri, Aiman ;
Hoogendoorn, Anita ;
Vazquez, Elenae ;
Storvall, Helena ;
Netusilova, Julie ;
Huch, Meritxell ;
Fischler, Bjorn ;
Ellis, Ewa ;
Contreras, Adriana ;
Nemeth, Antal ;
Chien, Kenneth C. ;
Clevers, Hans ;
Sandberg, Rickard ;
Bryja, Vitezslav ;
Lendahl, Urban .
GASTROENTEROLOGY, 2018, 154 (04) :1080-1095
[3]   A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells [J].
Ang, Lay Teng ;
Tan, Antson Kiat Yee ;
Autio, Matias I. ;
Goh, Su Hua ;
Choo, Siew Hua ;
Lee, Kian Leong ;
Tan, Jianmin ;
Pan, Bangfen ;
Lee, Jane Jia Hui ;
Lum, Jen Jen ;
Lim, Christina Ying Yan ;
Yeo, Isabelle Kai Xin ;
Wong, Chloe Jin Yee ;
Liu, Min ;
Oh, Jueween Ling Li ;
Chia, Cheryl Pei Lynn ;
Loh, Chet Hong ;
Chen, Angela ;
Chen, Qingfeng ;
Weissman, Irving L. ;
Loh, Kyle M. ;
Lim, Bing .
CELL REPORTS, 2018, 22 (08) :2190-2205
[4]  
[Anonymous], 2017, SCI REP UK
[5]  
[Anonymous], NATURE MULTILINEAGE
[6]  
[Anonymous], BIOCH BIOPHYSICA ACT
[7]  
[Anonymous], ARCH TOXICOLOGY
[8]   Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells [J].
Asai, Akihiro ;
Aihara, Eitaro ;
Watson, Carey ;
Mourya, Reena ;
Mizuochi, Tatsuki ;
Shivakumar, Pranavkumar ;
Phelan, Kieran ;
Mayhew, Christopher ;
Helmrath, Michael ;
Takebe, Takanori ;
Wells, James ;
Bezerra, Jorge A. .
DEVELOPMENT, 2017, 144 (06) :1056-1064
[9]   Hepatic organoids for microfluidic drug screening [J].
Au, Sam H. ;
Chamberlain, M. Dean ;
Mahesh, Shruthi ;
Sefton, Michael V. ;
Wheeler, Aaron R. .
LAB ON A CHIP, 2014, 14 (17) :3290-3299
[10]   Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling [J].
Ayabe, Hiroaki ;
Anada, Takahisa ;
Kamoya, Takuo ;
Sato, Tomoya ;
Kimura, Masaki ;
Yoshizawa, Emi ;
Kikuchi, Shunyuu ;
Ueno, Yasuharu ;
Sekine, Keisuke ;
Camp, J. Gray ;
Treutlein, Barbara ;
Ferguson, Autumn ;
Suzuki, Osamu ;
Takebe, Takanori ;
Taniguchi, Hideki .
STEM CELL REPORTS, 2018, 11 (02) :306-316
12345678910