Silencing of LIM and SH3 Protein 1 (LASP-1) Inhibits Thyroid Cancer Cell Proliferation and Invasion

被引：7

作者：

Gao, Wei ^{[1
]}

Han, Jiakai ^{[1
]}

机构：

[1] Henan Univ, Huaihe Hosp, Dept Endocrinol, 8 Baobei Rd, Kaifeng 475000, Henan Province, Peoples R China

来源：

ONCOLOGY RESEARCH | 2017年 / 25卷 / 06期

关键词：

LIM and SH3 protein 1 (LASP-1); Proliferation; Migration; Invasion; Thyroid cancer; ACTIN-BINDING; PATHWAY; PHOSPHORYLATION; CARCINOMA; MIGRATION; KINASE; TUMOR;

D O I：

10.3727/096504016X14785415155643

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

LIM and SH3 protein 1(LASP-1) is a specific focal adhesion protein that was first identified in breast cancer and then reported to be involved in cell proliferation and migration. Many studies have demonstrated the essential role of LASP-1 in cancer progression. However, there have been no studies on the association of LASP-1 with thyroid cancer. In this study, we investigated the expression pattern and biological function of LASP-1 in thyroid cancer. We found that LASP-1 was highly expressed in thyroid cancer tissues and cell lines. LASP-1 silencing had antiproliferative and anti-invasive effects on thyroid cancer cells. Moreover, tumor xenograft experiments showed that LASP-1 silencing suppressed thyroid cancer cell growth in vivo. We also demonstrated that LASP-1 silencing decreased the protein expression of p-PI3K and p-Akt. In conclusion, these findings suggest LASP-1 to be an oncogene and a potential therapeutic target in thyroid cancer.

引用

页码：879 / 886

页数：8

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