Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function

被引:24
作者
Gruol, Donna L. [1 ]
机构
[1] Scripps Res Inst, Mol & Cellular Neurosci Dept, La Jolla, CA 92037 USA
关键词
pyramidal neurons; Schaffer collaterals; LTP; neuroimmune; alcohol; field potential recordings; cytokine; chemokine; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; CCR2 CHEMOKINE RECEPTOR; TUMOR-NECROSIS-FACTOR; CEREBRAL OVEREXPRESSION; NEURONAL EXCITABILITY; RAT HIPPOCAMPUS; MOUSE MODEL; INTERLEUKIN-6; BRAIN;
D O I
10.3390/brainsci6020019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An important aspect of CNS disease and injury is the elevated expression of neuroimmune factors. These factors are thought to contribute to processes ranging from recovery and repair to pathology. The complexity of the CNS and the multitude of neuroimmune factors that are expressed in the CNS during disease and injury is a challenge to an understanding of the consequences of the elevated expression relative to CNS function. One approach to address this issue is the use of transgenic mice that express elevated levels of a specific neuroimmune factor in the CNS by a cell type that normally produces it. This approach can provide basic information about the actions of specific neuroimmune factors and can contribute to an understanding of more complex conditions when multiple neuroimmune factors are expressed. This review summarizes studies using transgenic mice that express elevated levels of IL-6, CCL2 or CXCL10 through increased astrocyte expression. The studies focus on the effects of these neuroimmune factors on synaptic function at the Schaffer collateral to CA1 pyramidal neuron synapse of the hippocampus, a brain region that plays a key role in cognitive function.
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页数:17
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