Aqueous Extract of Taegeuk Ginseng Inhibits Platelet Aggregation and Thrombus Formation

被引：2

作者：

Do, Jaeho ^{[1
]}

Gwak, Jungwon ^{[1
]}

Rho, Jung Jin ^{[1
]}

Lee, Kwangseung ^{[1
]}

Irfan, Muhammad ^{[2
]}

Rhee, Man Hee ^{[2
]}

Kim, Dong Chung ^{[3
]}

机构：

[1] Korea Ginseng MFG Co Ltd, Pyeongtaek, South Korea

[2] Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol & Signalling, Daegu, South Korea

[3] Chungwoon Univ, Dept Chem Engn, Incheon 22100, South Korea

来源：

JOURNAL OF MEDICINAL FOOD | 2018年 / 21卷 / 11期

关键词：

<bold>antithrombotic effect</bold>; <bold>platelet aggregation</bold>; <bold>taegeuk ginseng extract</bold>; <bold>thrombus formation</bold>; KOREAN RED GINSENG; PANAX-GINSENG; SAPONIN FRACTION; GINSENOSIDES; ANTIPLATELET; COMPONENTS; TOXICITY; CELLS;

D O I：

10.1089/jmf.2017.4145

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The inhibitory effects of taegeuk ginseng extract (TGE) on platelet aggregation and thrombus formation were investigated. The TGE significantly inhibited collagen- and adenosine 5-diphosphate (ADP)-induced platelet aggregation in vitro in a dose-dependent manner. Also oral administration of TGE to rats significantly prevented ADP- and collagen-induced platelet aggregation ex vivo, but it did not affect the plasma coagulation system. The oral administration of TGE significantly delayed the occlusion of the carotid artery in ferrous chloride-treated rats in vivo. These results suggest that in vivo antithrombotic effect of TGE may be due to its inhibitory activity on platelet aggregation rather than on plasma coagulation.

引用

页码：1137 / 1144

页数：8

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