Muscling in on the ryanodine receptor

被引：2
作者：
Kuo, Ivana Y.
Ehrlich, Barbara E. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2015年 / 22卷 / 02期
关键词：
RELEASE CHANNELS; RYR2; PHOSPHORYLATION; HEART-FAILURE; ION-CHANNEL; ARRHYTHMIAS;
D O I：
10.1038/nsmb.2960
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ryanodine receptor (RyR), an ion channel regulating intracellular calcium release in excitable cells, has been challenging for structural analysis because of its colossal proportions compared to most other ion channels. Three independent groups have now used recent technological advancements in single-particle cryo-EM to make giant strides in solving the structure of this elusive protein complex.
引用
收藏
页码：106 / 107
页数：2
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