Platelets, inflammation and atherosclerosis

被引：171

作者：

Lindemann, S. ^{[1
]}

Kraemer, B. ^{[1
]}

Seizer, P. ^{[1
]}

Gawaz, M. ^{[1
]}

机构：

[1] Univ Tubingen, Med Klin 3, D-72076 Tubingen, Germany

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2007年 / 5卷

关键词：

atherosclerosis; diffeerentiation; inflammation; platelets;

D O I：

10.1111/j.1538-7836.2007.02517.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An expanding body of evidence continues to build on the role of platelets as initial actors in the development of atherosclerotic lesions. Platelets bind to leukocytes and endothelial cells, and initiate monocyte transformation into macrophages. Platelets internalize oxidized phospholipids and promote foam cell formation. Platelets also recruit progenitor cells to the scene that are able to differentiate into foam cells or endothelial cells depending on conditions. Platelets tip the scales in the initiation, development and total extent of atherosclerotic lesions.

引用

页码：203 / 211

页数：9

共 92 条

[1] OLIGOSPECIFICITY OF THE CELLULAR ADHESION RECEPTOR MAC-1 ENCOMPASSES AN INDUCIBLE RECOGNITION SPECIFICITY FOR FIBRINOGEN [J].

ALTIERI, DC ;

BADER, R ;

MANNUCCI, PM ;

EDGINGTON, TS .

JOURNAL OF CELL BIOLOGY, 1988, 107 (05) :1893-1900

[2] Glycoprotein Ib-IX-mediated activation of integrin αIIbβ3:: effects of receptor clustering and von Willebrand factor adhesion [J].

Arya, M ;

López, JA ;

Romo, GM ;

Cruz, AA ;

Kasirer-Friede, A ;

Shattil, SJ ;

Anvari, B .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (06) :1150-1157

[3] The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis [J].

Bergmeier, Wolfgang ;

Piffath, Crystal L. ;

Goerge, Tobias ;

Cifuni, Stephen M. ;

Ruggeri, Zaverio M. ;

Ware, Jerry ;

Wagner, Denisa D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16900-16905

[4] Adhesion of activated platelets to endothelial cells:: Evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), αvβ3 integrin, and GPIbα [J].

Bombeli, T ;

Schwartz, BR ;

Harlan, JM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (03) :329-339

[5] IN VITRO INCORPORATION OF AMINO-ACIDS INTO CONTRACTILE PROTEIN OF HUMAN BLOOD PLATELETS [J].

BOOYSE, F ;

RAFELSON, ME .

NATURE, 1967, 215 (5098) :283-&

[6] STUDIES ON HUMAN PLATELETS .1. SYNTHESIS OF PLATELET PROTEIN IN A CELL-FREE SYSTEM [J].

BOOYSE, FM ;

RAFELSON, ME .

BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 166 (03) :689-&

[7] STABLE MESSENGER RNA IN SYNTHESIS OF CONTRACTILE PROTEIN IN HUMAN PLATELETS [J].

BOOYSE, FM ;

RAFELSON, ME .

BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 145 (01) :188-&

[8] STUDIES ON HUMAN PLATELETS .2. PROTEIN SYNTHETIC ACTIVITY OF VARIOUS PLATELET POPULATIONS [J].

BOOYSE, FM ;

HOVEKE, TP ;

RAFELSON, ME .

BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 157 (03) :660-&

[9] Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis [J].

Boring, L ;

Gosling, J ;

Cleary, M ;

Charo, IF .

NATURE, 1998, 394 (6696) :894-897

[10] High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib [J].

Chavakis, T ;

Santoso, S ;

Clemetson, KJ ;

Sachs, UJH ;

Isordia-Salas, I ;

Pixley, RA ;

Nawroth, PP ;

Colman, RW ;

Preissner, KT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) :45375-45381

← 1 2 3 4 5 6 7 8 9 10 →