Nitric Oxide Donors and Selective Carbonic Anhydrase Inhibitors: A Dual Pharmacological Approach for the Treatment of Glaucoma, Cancer and Osteoporosis

被引：41

作者：

Carradori, Simone ^{[1
]}

Mollica, Adriano ^{[1
]}

De Monte, Celeste ^{[2
]}

Granese, Arianna ^{[2
]}

Supuran, Claudiu T. ^{[3
]}

机构：

[1] G DAnnunzio Univ Chieti Pescara, Dept Pharm, I-66100 Chieti, Italy

[2] Univ Roma La Sapienza, Dept Drug Chem & Technol, I-00185 Rome, Italy

[3] Univ Florence, Lab Chim Bioinorgan, I-50019 Florence, Italy

来源：

MOLECULES | 2015年 / 20卷 / 04期

关键词：

NO donors; selective carbonic anhydrase inhibitors; glaucoma; cancer; osteoporosis; dual pharmacological activity; NO; DERIVATIVES; DRUGS; XII;

D O I：

10.3390/molecules20045667

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Due to the recognized biological role of nitric oxide (NO) donating derivatives and of selective inhibitors of specific human carbonic anhydrase isoforms (CA, EC 4.2.1.1), promising compounds having an aromatic/heterocyclic primary sulfonamide and functionalized with NO-releasing moieties have been designed. These bifunctional agents have been tested in vitro and in vivo to assess their dual pharmacological activity. According to the encouraging results they could be proposed for the treatment of angle-open glaucoma, cancer regression and osteoporosis, in which both NO and CA activities are involved.

引用

页码：5667 / 5679

页数：13

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