Study of recognition property of molecularly imprinted bovine hemoglobin on surface-modified silica gel

The silica modified with maleic anhydride was synthesized as a carrier material. Then, molecularly imprinted polymers based on the surface-modified silica gel were prepared by redox polymerization of acrylamide with N,N'-methylene bisacrylamide as the functional monomer and the crosslinker in the presence of bovine hemoglobin as a template molecule. The results of IR and scanning electron microscopy demonstrated the formation of a grafted polymer layer on the modified silica gel surface. The adsorption studies also showed that the imprinted polymers had good adsorption capacity and specific recognition for bovine hemoglobin in an aqueous solution.