Olfactory transmission of neurotropic viruses

被引：153

作者：

Mori, I

Nishiyama, Y

Yokochi, T

Kimura, Y

机构：

[1] Aichi Med Univ, Sch Med, Res Ctr Infect Dis, Dept Microbiol & Immunol, Nagakute, Aichi 48011, Japan

[2] Nagoya Univ, Grad Sch Med, Dis Mech & Control Res Inst, Virol Lab, Nagoya, Aichi, Japan

[3] Fukui Med Univ Sch Med, Dept Microbiol, Fukui, Japan

来源：

JOURNAL OF NEUROVIROLOGY | 2005年 / 11卷 / 02期

关键词：

axon; dendrite; nervous system; olfactory receptor neuron; prion; virus;

D O I：

10.1080/13550280590922793

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Olfactory receptor neurons are unique in their anatomical structure and function. Each neuron is directly exposed to the external environment at the site of its dendritic nerve terminals where it is exposed to macromolecules. These molecules can be incorporated into by olfactory receptor neurons and transported transsynaptically to the central nervous system. Certain neurotropic pathogens such as herpes simplex virus and Borna disease virus make use of this physiological mechanism to invade the brain. Here the authors review the olfactory transmission of infectious agents and the resulting hazards to human and animal health.

引用

页码：129 / 137

页数：9

共 78 条

[61]

Schwob James E., 2002, Anatomical Record, V269, P33, DOI 10.1002/ar.10047

[62] BSE AND FARMWORKERS [J].