Olfactory transmission of neurotropic viruses

被引：151

作者：

Mori, I

Nishiyama, Y

Yokochi, T

Kimura, Y

机构：

[1] Aichi Med Univ, Sch Med, Res Ctr Infect Dis, Dept Microbiol & Immunol, Nagakute, Aichi 48011, Japan

[2] Nagoya Univ, Grad Sch Med, Dis Mech & Control Res Inst, Virol Lab, Nagoya, Aichi, Japan

[3] Fukui Med Univ Sch Med, Dept Microbiol, Fukui, Japan

来源：

JOURNAL OF NEUROVIROLOGY | 2005年 / 11卷 / 02期

关键词：

axon; dendrite; nervous system; olfactory receptor neuron; prion; virus;

D O I：

10.1080/13550280590922793

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Olfactory receptor neurons are unique in their anatomical structure and function. Each neuron is directly exposed to the external environment at the site of its dendritic nerve terminals where it is exposed to macromolecules. These molecules can be incorporated into by olfactory receptor neurons and transported transsynaptically to the central nervous system. Certain neurotropic pathogens such as herpes simplex virus and Borna disease virus make use of this physiological mechanism to invade the brain. Here the authors review the olfactory transmission of infectious agents and the resulting hazards to human and animal health.

引用

收藏

页码：129 / 137

页数：9

相关论文

共 78 条

[1] Peripheral prion pursuit [J].

Aguzzi, A .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (05) :661-662

[2] A glycine-rich bovine herpesvirus 5 (BHV-5) gE-specific epitope within the ectodomain is important for BHV-5 neurovirulence [J].

Al-Mubarak, A ;

Zhou, Y ;

Chowdhury, SI .

JOURNAL OF VIROLOGY, 2004, 78 (09) :4806-4816

[3] Invasion and persistence of the neuroadapted influenza virus A/WSN/33 in the mouse olfactory system [J].

Aronsson, F ;

Robertson, B ;

Ljunggren, HG ;

Kristensson, K .

VIRAL IMMUNOLOGY, 2003, 16 (03) :415-423

[4] THE CVS STRAIN OF RABIES VIRUS AS TRANSNEURONAL TRACER IN THE OLFACTORY SYSTEM OF MICE [J].

ASTIC, L ;

SAUCIER, D ;

COULON, P ;

LAFAY, F ;

FLAMAND, A .

BRAIN RESEARCH, 1993, 619 (1-2) :146-156

[5] HERPES-SIMPLEX VIRUS GENOMES IN HUMAN NERVOUS-SYSTEM TISSUE ANALYZED BY POLYMERASE CHAIN-REACTION [J].

BARINGER, JR ;

PISANI, P .

ANNALS OF NEUROLOGY, 1994, 36 (06) :823-829

[6] HSV-1 BRAIN INFECTION BY THE OLFACTORY NERVE ROUTE AND VIRUS LATENCY AND REACTIVATION MAY CAUSE LEARNING AND BEHAVIORAL DEFICIENCIES AND VIOLENCE IN CHILDREN AND ADULTS - A POINT-OF-VIEW [J].

BECKER, Y .

VIRUS GENES, 1995, 10 (03) :217-226

[7] SPATIAL RECOGNITION MEMORY DEFICITS WITHOUT NOTABLE CNS PATHOLOGY IN RATS FOLLOWING HERPES-SIMPLEX ENCEPHALITIS [J].

BEERS, DR ;

HENKEL, JS ;

KESNER, RP ;

STROOP, WG .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1995, 131 (02) :119-127

[8] NEUROPATHOLOGY OF HERPES-SIMPLEX VIRUS ENCEPHALITIS IN A RAT SEIZURE MODEL [J].

BEERS, DR ;

HENKEL, JS ;

SCHAEFER, DC ;

ROSE, JW ;

STROOP, WG .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1993, 52 (03) :241-252

[9] Wild birds as a possible natural reservoir of Borna disease virus [J].

Berg, M ;

Johansson, M ;

Montell, H ;

Berg, AL .

EPIDEMIOLOGY AND INFECTION, 2001, 127 (01) :173-178

[10] Asymptomatic herpes simplex type 1 virus infection of the mouse brain [J].

Boggian, I ;

Buzzacaro, E ;

Calistri, A ;

Calvi, P ;

Cavaggioni, A ;

Mucignat-Caretta, C ;

Palu, G .

JOURNAL OF NEUROVIROLOGY, 2000, 6 (04) :303-313

← 1 2 3 4 5 6 7 8 →