NMR spectroscopy as a tool for structure-based drug design

被引：48

作者：

Stockman, BJ ^{[1
]}

机构：

[1] Pharmacia & Upjohn Inc, Kalamazoo, MI 49001 USA

来源：

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | 1998年 / 33卷

关键词：

drug design; inhibitor; ligand; NMR spectroscopy; protein; receptor; structure-based drug design;

D O I：

10.1016/S0079-6565(98)00020-X

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

[No abstract available]

引用

页码：109 / 151

页数：43

共 274 条

[1] SOLUTION STRUCTURE OF KISTRIN, A POTENT PLATELET-AGGREGATION INHIBITOR AND GP-IIB-IIIA ANTAGONIST [J].

ADLER, M ;

LAZARUS, RA ;

DENNIS, MS ;

WAGNER, G .

SCIENCE, 1991, 253 (5018) :445-448

[2] SYNTHESIS, CONFORMATION, AND IMMUNOSUPPRESSIVE ACTIVITY OF A CONFORMATIONALLY RESTRICTED CYCLOSPORINE LACTAM ANALOG [J].

AEBI, JD ;

GUILLAUME, D ;

DUNLAP, BE ;

RICH, DH .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (09) :1805-1815

[3] SYNTHESIS, CONFORMATION, AND IMMUNOSUPPRESSIVE ACTIVITIES OF 3 ANALOGS OF CYCLOSPORINE-A MODIFIED IN THE 1-POSITION [J].

AEBI, JD ;

DEYO, DT ;

CHONG, QS ;

GUILLAUME, D ;

DUNLAP, B ;

RICH, DH .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (03) :999-1009

[4] EFFECTS OF ION-BINDING ON THE BACKBONE DYNAMICS OF CALBINDIN-D9K DETERMINED BY N-15 NMR RELAXATION [J].

AKKE, M ;

SKELTON, NJ ;

KORDEL, J ;

PALMER, AG ;

CHAZIN, WJ .

BIOCHEMISTRY, 1993, 32 (37) :9832-9844

[5] STRUCTURE-BASED DESIGN OF A CYCLOPHILIN-CALCINEURIN BRIDGING LIGAND [J].

ALBERG, DG ;

SCHREIBER, SL .

SCIENCE, 1993, 262 (5131) :248-250

[6] fd coat protein structure in membrane environments: Structural dynamics of the loop between the hydrophobic trans-membrane helix and the amphipathic in-plane helix [J].

Almeida, FCL ;

Opella, SJ .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 270 (03) :481-495

[7] ANALYTICAL TECHNIQUES IN COMBINATORIAL CHEMISTRY - MAS CH CORRELATION IN SOLVENT-SWOLLEN RESIN [J].

ANDERSON, RC ;

JAREMA, MA ;

SHAPIRO, MJ ;

STOKES, JP ;

ZILIOX, M .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (09) :2650-2651

[8] STRUCTURE DETERMINATION IN COMBINATORIAL CHEMISTRY - UTILIZATION OF MAGIC-ANGLE-SPINNING HMQC AND TOCSY NMR-SPECTRA IN THE STRUCTURE DETERMINATION OF WANG-BOUND LYSINE [J].

ANDERSON, RC ;

STOKES, JP ;

SHAPIRO, MJ .

TETRAHEDRON LETTERS, 1995, 36 (30) :5311-5314

[9] DESIGN OF ENZYME-INHIBITORS USING ITERATIVE PROTEIN CRYSTALLOGRAPHIC ANALYSIS [J].

APPELT, K ;

BACQUET, RJ ;

BARTLETT, CA ;

BOOTH, CLJ ;

FREER, ST ;

FUHRY, MAM ;

GEHRING, MR ;

HERRMANN, SM ;

HOWLAND, EF ;

JANSON, CA ;

JONES, TR ;

KAN, CC ;

KATHARDEKAR, V ;

LEWIS, KK ;

MARZONI, GP ;

MATTHEWS, DA ;

MOHR, C ;

MOOMAW, EW ;

MORSE, CA ;

OATLEY, SJ ;

OGDEN, RC ;

REDDY, MR ;

REICH, SH ;

SCHOETTLIN, WS ;

SMITH, WW ;

VARNEY, MD ;

VILLAFRANCA, JE ;

WARD, RW ;

WEBBER, S ;

WEBBER, SE ;

WELSH, KM ;

WHITE, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (07) :1925-1934

[10]

Archer SJ, 1996, ANNU REP MED CHEM, V31, P299

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