Sequential Analysis of Neutrophil-to-lymphocyte Ratio for Differentiated Thyroid Cancer Patients Treated With Lenvatinib

被引：30
作者：
Fukuda, Naoki [1 ]
Wang, Xiaofei [1 ]
Ohmoto, Akihiro [1 ]
Urasaki, Tetsuya [1 ]
Sato, Yasuyoshi [1 ]
Nakano, Kenji [1 ]
Nishizawa, Masatoshi [1 ]
Yunokawa, Mayu [1 ]
Ono, Makiko [1 ]
Tomomatsu, Junichi [1 ]
Takahashi, Shunji [1 ]
机构：
[1] JFCR, Canc Inst Hosp, Dept Med Oncol, Tokyo, Japan
来源：
IN VIVO | 2020年 / 34卷 / 02期
基金：
日本学术振兴会;
关键词：
Thyroid cancer; lenvatinib; neutrophil-to-lymphocyte ratio; prognostic factors; ANTITUMOR ACTIVITIES; INHIBITOR; E7080; CARCINOMA; IMPACT;
D O I：
10.21873/invivo.11828
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: Neutrophil-to-lymphocyte ratio (NLR) has been reported to be associated with poor prognosis for radioactive iodine ablation refractory differentiated thyroid cancer (RR-DTC). Little is known whether NLR can be a tumor marker for RR-DTC patients treated with lenvatinib. Patients and Methods: We retrospectively analyzed RR-DTC patients treated with lenvatinib. NLR was calculated at 4 points before and during lenvatinib treatment. Results: The median NLR value increased at the start of lenvatinib treatment, compared to 6 months prior to initiation of lenvatinib treatment. The median overall survival was significantly longer in patients with the lower NLR (<3) at the start of lenvatinib treatment. The median NLR values decreased when the patients achieved best tumor response, and increased again upon disease progression. Conclusion: NLR values vary before and during lenvatinib treatment, suggesting that this ratio can reflect disease activity of RR-DTC. NLR can supportively be used as a tumor marker of RR-DTC and an indicator for starting lenvatinib treatment.
引用
收藏
页码：709 / 714
页数：6
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