Three-component green synthesis of 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, a promising antituberculosis drug

被引：7
|
作者：
Titova, Yu. A. [1 ]
Fedorova, O. V. [1 ]
Rusinov, G. L. [1 ,2 ]
Charushin, V. N. [1 ,2 ]
机构：
[1] Russian Acad Sci, I Ya Postovsky Inst Organ Synth, Ural Branch, 22 Ul S Kovalevskoi, Ekaterinburg 620990, Russia
[2] Ural Fed Univ, 19 Ul Mira, Ekaterinburg 620002, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2019年 / 68卷 / 12期
基金：
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词：
dihydroazolopyrimidine; green chemistry; nanosized oxides; Biginelli reaction; NANOSIZED METAL-OXIDES;
D O I：
10.1007/s11172-019-2698-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new simple, technological, and environmentally friendly method for the catalyst-free synthesis in water of a promising antituberculosis drug, 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, was developed. The amount of the solvent in the reaction mixture has a decisive effect on the yield and purity of the target product.
引用
收藏
页码：2271 / 2274
页数：4
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