Impact of concomitant atrial fibrillation on the prognosis of Takotsubo cardiomyopathy

被引：58

作者：

El-Battrawy, Ibrahim ^{[1
,2
]}

Lang, Siegfried ^{[1
,2
]}

Ansari, Uzair ^{[1
]}

Behnes, Michael ^{[1
]}

Hillenbrand, Dennis ^{[1
]}

Schramm, Katja ^{[1
]}

Fastner, Christian ^{[1
]}

Zhou, Xiaobo ^{[1
,2
]}

Bill, Verena ^{[1
]}

Hoffmann, Ursula ^{[1
]}

Papavassiliu, Theano ^{[1
,2
]}

Elmas, Elif ^{[1
]}

Haghi, Darius ^{[1
]}

Borggrefe, Martin ^{[1
,2
]}

Akin, Ibrahim ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Univ Med Ctr Mannheim UMM, Fac Med, Dept Med 1, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany

[2] DZHK German Ctr Cardiovasc Res, Partner Site, Mannheim, Germany

来源：

EUROPACE | 2017年 / 19卷 / 08期

关键词：

Takotsubo cardiomyopathy; Atrial fibrillation; Mortality; Stroke; APICAL BALLOONING SYNDROME; TAKO-TSUBO CARDIOMYOPATHY; CLINICAL CHARACTERISTICS; MYOCARDIAL-INFARCTION; HEART-FAILURE; RISK-FACTORS; STRESS; COMPLICATIONS; METAANALYSIS; ARRHYTHMIAS;

D O I：

10.1093/europace/euw293

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Previous studies revealed that patients with Takotsubo cardiomyopathy (TTC) have a higher mortality rate than the general population. Supraventricular tachycardia is a well-known complication of TTC. This study was performed to determine the short-and long-term prognostic impact of atrial fibrillation associated with TTC patients. Methods and results Our institutional database constituted a collective of 114 patients diagnosed with TTC from 2003 to 2015. The patients were divided into two groups according to the presence (n = 21, 18.4%) or absence (n = 93, 81.5%) of atrial fibrillation. The endpoint was a composite of in-hospital events (thromboembolic events and life-threatening arrhythmias), allcause mortality, rehospitalization due to heart failure, stroke, and the recurrence of TTC. The in-hospital mortality, 30-day mortality, and long-term mortality were significantly higher in the atrial fibrillation group. Kaplan-Meier analysis indicated a significantly lower event-free survival rate over a mean follow-up of 3 years in the atrial fibrillation group than that in the non-atrial fibrillation group (log-rank, P < 0.01). In a multivariate cox regression analysis, atrial fibrillation (hazard ratio, HR 2.3, 95% confidence interval, CI: 1.1-4.9, P < 0.05) and EF <= 35% (HR 2.0, 95% CI: 1.1-3.8, P < 0.05) were the only independent predictors of a primary endpoint. Conclusion Rates of in-hospital events and short-as well as long-term mortality were significantly higher in TTC patients suffering from atrial fibrillation compared with patients without atrial fibrillation.

引用

页码：1288 / 1292

页数：5