Synthesis of Indoles through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone

被引：48

作者：

Zhou, Bo ^{[1
]}

Wu, Zhuo ^{[1
]}

Ma, Ding ^{[1
]}

Ji, Xiaoming ^{[1
]}

Zhang, Yanghui ^{[1
]}

机构：

[1] Tongji Univ, Shanghai Key Lab Chem Assessment & Sustainabil, Sch Chem Sci & Engn, 1239 Siping Rd, Shanghai 200092, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 20期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; INTERNAL ALKYNES; BOND FORMATION; N BOND; 1,4-PALLADIUM MIGRATION; EFFICIENT SYNTHESIS; DIRECTING GROUP; ANNULATION; FUNCTIONALIZATION; INDOLIZATION;

D O I：

10.1021/acs.orglett.8b02750

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The three-component reaction of aryl iodides, alkynes, and diaziridinone is described. The reaction provides an innovative synthetic approach for indoles. The approach features high efficiency, broad substrate scope, and excellent regioselectivity. C,C-Palladacycles should act as the intermediates. The C,C-palladacycles are obtained from simple aryl halides and alkynes and then reacted with diaziridinone to afford indoles.

引用

页码：6440 / 6443

页数：4

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