Parameiosis in Aspergillus nidulans in response to doxorubicin

被引：7
作者：
Becker, TCA [1 ]
de Castro-Prado, MAA [1 ]
机构：
[1] Univ Estadual Maringa, Dept Cell Biol & Genet, Maringa, Parana, Brazil
来源：
FOLIA MICROBIOLOGICA | 2004年 / 49卷 / 06期
关键词：
D O I：
10.1007/BF02931552
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The recombinagenic effect of doxorubicin (an anticancer agent that impairs DNA synthesis and causes chromosome breaks) was used to induce parameiotic events in Aspergillus nidulans. Heterokaryons formed with master strains and uvs mutants were inoculated with and without doxorubicin. Haploid segregants (parameiotics and parents) and aneuploids were selected as heterokaryon-derived visible sectors. Among parameiotic segregants, recombinants by intergenic mitotic crossing-over and recombinants by chromosome-independent segregation were found. Whereas segregants of the former type were obtained only with doxorubicin, those of the latter type were recovered both with and without the drug.
引用
收藏
页码：699 / 704
页数：6
相关论文
共 23 条
  • [1] Aly MS, 1999, ENVIRON MOL MUTAGEN, V33, P161, DOI 10.1002/(SICI)1098-2280(1999)33:2<161::AID-EM8>3.0.CO
  • [2] 2-M
  • [3] Mutagenic properties of topoisomerase-targeted drugs
    Baguley, BC
    Ferguson, LR
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1400 (1-3): : 213 - 222
  • [4] Alternative reproduction pathway in Aspergillus nidulans
    Baptista, F
    Machado, MFPS
    Castro-Prado, MAA
    [J]. FOLIA MICROBIOLOGICA, 2003, 48 (05) : 597 - 604
  • [5] Increase in mitotic recombination in diploid cells of Aspergillus nidulans in response to ethidium bromide
    Becker, TCA
    Chiuchetta, SJR
    Baptista, F
    de Castro-Prado, MAA
    [J]. GENETICS AND MOLECULAR BIOLOGY, 2003, 26 (03) : 381 - 385
  • [6] Localization of auxotrophic and benomyl resistance markers through the parasexual cycle in the Beauveria bassiana (Bals.) vuill entomopathogen
    Bello, VA
    Paccola-Meirelles, LD
    [J]. JOURNAL OF INVERTEBRATE PATHOLOGY, 1998, 72 (02) : 119 - 125
  • [7] Boege F, 1996, EUR J CLIN CHEM CLIN, V34, P873
  • [8] Chabner B., 1996, GOODMAN GILMANS PHAR, P1233
  • [9] Recombinagenic effect of cryptolepine in uvsH+//uvsH+ and uvsH//uvsH diploid strains of Aspergillus nidulans
    Chiuchetta, SJR
    Castro-Prado, MAA
    [J]. FOLIA MICROBIOLOGICA, 2002, 47 (05) : 516 - 520
  • [10] ESPOSITO RE, 1964, GENETICS, V50, P1009
123