Ferritin level: A predictor of severity and mortality in hospitalized COVID-19 patients

被引：47

作者：

Alroomi, Moudhi ^{[1
]}

Rajan, Rajesh ^{[2
]}

Omar, Abdulaziz A. ^{[3
]}

Alsaber, Ahmad ^{[4
]}

Pan, Jiazhu ^{[4
]}

Fatemi, Mina ^{[5
]}

Zhanna, Kobalava D. ^{[6
]}

Aboelhassan, Wael ^{[7
]}

Almutairi, Farah ^{[8
]}

Alotaibi, Naser ^{[9
]}

Saleh, Mohammad A. ^{[8
]}

AlNasrallah, Noor ^{[9
]}

Al-Bader, Bader ^{[8
]}

Malhas, Haya ^{[10
]}

Ramadhan, Maryam ^{[11
]}

Abdullah, Mohammed ^{[1
]}

Abdelnaby, Hassan ^{[12
,13
]}

机构：

[1] Infect Dis Hosp, Dept Infect Dis, Kuwait, Kuwait

[2] Al Amiri Hosp, Sabah Al Ahmad Cardiac Ctr, Dept Cardiol, Kuwait 15303, Kuwait

[3] Jaber Al Ahmed Hosp, Dept Med, South Surra, Kuwait

[4] Univ Strathclyde, Dept Math & Stat, Glasgow, Lanark, Scotland

[5] Nottinghamshire Cty Council, Nottingham, England

[6] Peoples Friendship Univ Russia, Dept Internal Med Subspecialty Cardiol & Funct Di, RUDN Univ, Moscow, Russia

[7] Jaber Al Ahmed Hosp, Dept Med, Div Gastroenterol, South Surra, Kuwait

[8] Farwaniya Hosp, Dept Med, Farwaniya, Kuwait

[9] Al Adan Hosp, Dept Med, Hadiya, Kuwait

[10] Mubarak Al Kabeer Hosp, Dept Emergency Med, Jabriya, Kuwait

[11] Matern Hosp, Dept Obstet & Gynaecol, Kuwait, Kuwait

[12] Suez Canal Univ, Fac Med, Dept Endem & Infect Dis, Ismailia, Kuwait

[13] Al Sabah Hosp, Dept Med, Div Gastroenterol, Kuwait, Kuwait

来源：

IMMUNITY INFLAMMATION AND DISEASE | 2021年 / 9卷 / 04期

关键词：

COVID-19; ferritin; hypertension; in-hospital mortality; male sex; pneumonia; SARS-CoV-2;

D O I：

10.1002/iid3.517

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: This study aims to investigate in-hospital mortality in severe acute respiratory syndrome coronavirus 2 patients stratified by serum ferritin levels. Methods: Patients were stratified based on ferritin levels (ferritin levels <= 1000 or >1000). Results: Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21-0.62; p < .001), male sex (OR = 2.63, 95% CI = 1.43-5.06; p = .003), hypertension (OR = 4.16, 95% CI = 2.42-7.36; p < .001) and pneumonia (OR = 8.48, 95% CI = 3.02-35.45; p < .001) had significance in predicting in-hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan-Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000. Conclusion: In this study, higher levels of serum ferritin were found to be an independent predictor of in-hospital mortality.

引用

页码：1648 / 1655

页数：8

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