Hyphenated MS-based targeted approaches in metabolomics

被引:67
作者
Begou, O. [1 ]
Gika, H. G. [2 ]
Wilson, I. D. [3 ]
Theodoridis, G. [1 ]
机构
[1] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Dept Med, Thessaloniki 54124, Greece
[3] Imperial Coll, Dept Surg & Canc, Div Computat & Syst Med, London, England
关键词
PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; CAPILLARY-ELECTROPHORESIS; AMINO-ACIDS; HIGH-THROUGHPUT; HEPATOCELLULAR-CARCINOMA; QUANTITATIVE-ANALYSIS; INTRACELLULAR METABOLITES; ANALYTICAL STRATEGIES; INDUCED FLUORESCENCE;
D O I
10.1039/c7an00812k
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
While global metabolic profiling (untargeted metabolomics) has been the center of much interest and research activity in the past few decades, more recently targeted metabolomics approaches have begun to gain ground. These analyses are, to an extent, more hypothesis-driven, as they focus on a set of pre-defined metabolites and aim towards their determination, often to the point of absolute quantification. The continuous development of the technological platforms used in these studies facilitates the analysis of large numbers of well-characterized metabolites present in complex matrices. The present review describes recent developments in the hyphenated chromatographic methods most often applied in targeted metabolomic/lipidomic studies (LC-MS/MS, CE-MS/MS, and GC-MS/MS), highlighting applications in the life and food/plant sciences. The review also underlines practical challenges-limitations that appear in such approaches.
引用
收藏
页码:3079 / 3100
页数:22
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