Diabetes and Cognition

被引：87

作者：

Mayeda, Elizabeth Rose ^{[1
]}

Whitmer, Rachel A. ^{[2
]}

Yaffe, Kristine ^{[3
,4
,5
,6
]}

机构：

[1] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94107 USA

[2] Kaiser Permanente, Div Res, Oakland, CA 94612 USA

[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[6] San Francisco VA Med Ctr, San Francisco, CA 94121 USA

来源：

CLINICS IN GERIATRIC MEDICINE | 2015年 / 31卷 / 01期

关键词：

Type; 2; diabetes; Cognition; Cognitive decline; Dementia; Aging; Epidemiology; VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; DEMENTIA RISK; OXIDATIVE DAMAGE; OLDER-ADULTS; FOLLOW-UP; DECLINE; MELLITUS; IMPAIRMENT; DEPRESSION;

D O I：

10.1016/j.cger.2014.08.021

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Dementia is a major cause of disability and death among older adults. Those with type 2 diabetes (T2D) are 50-100% more likely to develop dementia than those without T2D, but it is unknown whether this association reflects a causal relationship. Proposed mechanisms through which T2D could cause dementia include the effects of insulin dysregulation and chronic hyperglycemia on features of Alzheimer's disease and macrovascular and microvascular disorders in the brain. More research is needed to elucidate the link between T2D and dementia and identify strategies to maintain cognitive function among people with T2D.

引用

页码：101 / +

页数：16

共 92 条

[21] Type 2 Diabetes and Late-Onset Alzheimer's Disease [J].

Cheng, D. ;

Noble, J. ;

Tang, M. X. ;

Schupf, N. ;

Mayeux, R. ;

Luchsinger, J. A. .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2011, 31 (06) :424-430

[22] Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies [J].

Cheng, G. ;

Huang, C. ;

Deng, H. ;

Wang, H. .

INTERNAL MEDICINE JOURNAL, 2012, 42 (05) :484-491

[23] Somatic chronic diseases and 6-year change in cognitive functioning among older persons [J].

Comijs, Hannie C. ;

Kriegsman, Didi M. W. ;

Dik, Miranda G. ;

Deeg, Dorly J. H. ;

Jonker, Cees ;

Stalman, Wirn A. B. .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2009, 48 (02) :191-196

[24] Insulin and Alzheimer's Disease: Untangling the Web [J].

Craft, Suzanne ;

Cholerton, Brenna ;

Baker, Laura D. .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 33 :S263-S275

[25] The Role of Insulin Dysregulation in Aging and Alzheimer's Disease [J].

Craft, Suzanne .

DIABETES, INSULIN AND ALZHEIMER'S DISEASE, 2010, :109-127

[26]

Crane PK, 2013, NEW ENGL J MED, V369, P540, DOI [10.1056/NEJMoa1215740, 10.1056/NEJMc1311765]

[27] Inflammation: the link between insulin resistance, obesity and diabetes [J].

Dandona, P ;

Aljada, A ;

Bandyopadhyay, A .

TRENDS IN IMMUNOLOGY, 2004, 25 (01) :4-7

[28] Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline [J].

Debette, S. ;

Seshadri, S. ;

Beiser, A. ;

Au, R. ;

Himali, J. J. ;

Palumbo, C. ;

Wolf, P. A. ;

DeCarli, C. .

NEUROLOGY, 2011, 77 (05) :461-468

[29] Co-occurrence of Different Pathologies in Dementia: Implications for Dementia Diagnosis [J].

Echavarri, Carmen ;

Burgmans, Saartje ;

Cristina Caballero, Maria ;

Garcia-Bragado, Federico ;

Verhey, Frans R. J. ;

Uylings, Harry B. M. .

JOURNAL OF ALZHEIMERS DISEASE, 2012, 30 (04) :909-917

[30] Influence of Type 2 Diabetes on Brain Volumes and Changes in Brain Volumes Results from the Women's Health Initiative Magnetic Resonance Imaging Studies [J].

Espeland, Mark A. ;

Bryan, R. Nick ;

Goveas, Joseph S. ;

Robinson, Jennifer G. ;

Siddiqui, Mustafa S. ;

Liu, Simin ;

Hogan, Patricia E. ;

Casanova, Ramon ;

Coker, Laura H. ;

Yaffe, Kristine ;

Masaki, Kamal ;

Rossom, Rebecca ;

Resnick, Susan M. .

DIABETES CARE, 2013, 36 (01) :90-97

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