Combined Use of Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses Is a Powerful Diagnostic Tool of Active Tuberculosis

被引：72

作者：

Rozot, Virginie ^{[1
,2
]}

Patrizia, Amelio ^{[1
]}

Vigano, Selena ^{[1
]}

Mazza-Stalder, Jesica ^{[3
]}

Idrizi, Elita ^{[1
]}

Day, Cheryl L. ^{[2
]}

Perreau, Matthieu ^{[1
]}

Lazor-Blanchet, Catherine ^{[4
]}

Ohmiti, Khalid ^{[1
]}

Goletti, Delia ^{[5
]}

Bart, Pierre-Alexandre ^{[1
]}

Hanekom, Willem ^{[2
]}

Scriba, Thomas J. ^{[2
]}

Nicod, Laurent ^{[3
]}

Pantaleo, Giuseppe ^{[1
,6
]}

Harari, Alexandre ^{[1
,6
]}

机构：

[1] Univ Lausanne Hosp, Div Immunol & Allergy, CH-1011 Lausanne, Switzerland

[2] Univ Cape Town, Inst Infect Dis & Mol Med, South African TB Vaccine Initiat, ZA-7700 Rondebosch, South Africa

[3] Univ Lausanne, CHU Vaudois, Div Pneumol, CH-1015 Lausanne, Switzerland

[4] Univ Lausanne, CHU Vaudois, CH-1015 Lausanne, Switzerland

[5] Natl Inst Infect Dis, Rome, Italy

[6] Swiss Vaccine Res Inst, Lausanne, Switzerland

来源：

CLINICAL INFECTIOUS DISEASES | 2015年 / 60卷 / 03期

关键词：

diagnosis; active tuberculosis disease; latent Mtb infection; functional profile; CD8 T cells; LATENT INFECTION; ASSAY; SIGNATURE; CHILDREN; DISEASE; HUMANS;

D O I：

10.1093/cid/ciu795

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection.

引用

收藏

页码：432 / 437

页数：6

相关论文

共 22 条

[1] Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis [J].

Behar, SM ;

Dascher, CC ;

Grusby, MJ ;

Wang, CR ;

Brenner, MB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (12) :1973-1980

[2] An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis [J].

Berry, Matthew P. R. ;

Graham, Christine M. ;

McNab, Finlay W. ;

Xu, Zhaohui ;

Bloch, Susannah A. A. ;

Oni, Tolu ;

Wilkinson, Katalin A. ;

Banchereau, Romain ;

Skinner, Jason ;

Wilkinson, Robert J. ;

Quinn, Charles ;

Blankenship, Derek ;

Dhawan, Ranju ;

Cush, John J. ;

Mejias, Asuncion ;

Ramilo, Octavio ;

Kon, Onn M. ;

Pascual, Virginia ;

Banchereau, Jacques ;

Chaussabel, Damien ;

O'Garra, Anne .

NATURE, 2010, 466 (7309) :973-U98

[3] Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans [J].

Bruns, Heiko ;

Meinken, Christoph ;

Schauenberg, Philipp ;

Haerter, Georg ;

Kern, Peter ;

Modlin, Robert L. ;

Antoni, Christian ;

Stenger, Steffen .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (05) :1167-1177

[4] Cell-Mediated Immune Responses in Tuberculosis [J].

Cooper, Andrea M. .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :393-422

[5] Functional Capacity of Mycobacterium tuberculosis-Specific T Cell Responses in Humans Is Associated with Mycobacterial Load [J].

Day, Cheryl L. ;

Abrahams, Deborah A. ;

Lerumo, Lesedi ;

van Rensburg, Esme Janse ;

Stone, Lynnett ;

O'rie, Terrence ;

Pienaar, Bernadette ;

de Kock, Marwou ;

Kaplan, Gilla ;

Mahomed, Hassan ;

Dheda, Keertan ;

Hanekom, Willem A. .

JOURNAL OF IMMUNOLOGY, 2011, 187 (05) :2222-2232

[6] Tuberculin skin test versus interferon-gamma release assays for the diagnosis of tuberculosis infection [J].

De Keyser, E. ;

De Keyser, F. ;

De Baets, F. .

ACTA CLINICA BELGICA, 2014, 69 (05) :358-366

[7] Bifunctional T-Cell-Derived Cytokines for the Diagnosis of Tuberculosis and Treatment Monitoring [J].

Essone, Paulin N. ;

Kalsdorf, Barbara ;

Chegou, Novel N. ;

Loxton, Andre G. ;

Kriel, Magdalena ;

Preyer, Rosemarie ;

Ernst, Martin ;

Walzl, Gerhard ;

Lange, Christoph .

RESPIRATION, 2014, 88 (03) :251-261

[8] Immunology of tuberculosis [J].

Flynn, JL ;

Chan, J .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :93-129

[9] Dominant TNF-α+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease [J].

Harari, Alexandre ;

Rozot, Virginie ;

Enders, Felicitas Bellutti ;

Perreau, Matthieu ;

Stalder, Jesica Mazza ;

Nicod, Laurent P. ;

Cavassini, Matthias ;

Calandra, Thierry ;

Blanchet, Catherine Lazor ;

Jaton, Katia ;

Faouzi, Mohamed ;

Day, Cheryl L. ;

Hanekom, Willem A. ;

Bart, Pierre-Alexandre ;

Pantaleo, Giuseppe .

NATURE MEDICINE, 2011, 17 (03) :372-U174

[10] HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells [J].

Heinzel, AS ;

Grotzke, JE ;

Lines, RA ;

Lewinsohn, DA ;

McNabb, AL ;

Streblow, DN ;

Brand, VM ;

Grieser, HJ ;

Belisle, JT ;

Lewinsohn, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (11) :1473-1481