New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation

被引：35

作者：

Cen Pacheco, Francisco ^{[1
]}

Villa-Pulgarin, Janny A. ^{[2
,3
]}

Mollinedo, Faustino ^{[2
]}

Norte Martin, Manuel ^{[1
]}

Javier Fernandez, Jose ^{[1
]}

Hernandez Daranas, Antonio ^{[1
]}

机构：

[1] Univ La Laguna, Univ Inst Bioorgan Chem Antonio Gonzalez IUBO, E-38206 Tenerife, Spain

[2] Univ Salamanca, CSIC, Canc Res Ctr, Inst Mol & Cellular Biol Canc, E-37007 Salamanca, Spain

[3] Sci Pk Univ Salamanca, APOINTECH, Spanish Portuguese Ctr Agr Res CIALE, E-37185 Tenerife, Spain

来源：

MARINE DRUGS | 2011年 / 9卷 / 11期

关键词：

Laurencia viridis; squalene; polyethers; cytotoxic activity; SQUALENE-DERIVED TRITERPENES; MARINE NATURAL-PRODUCTS; APOPTOSIS;

D O I：

10.3390/md9112220

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)-dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.

引用

页码：2220 / 2235

页数：16

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