Proportion of Patients Treated With Thrombolysis in a Centralized Versus a Decentralized Acute Stroke Care Setting

被引:64
作者
Lahr, Maarten M. H. [1 ]
Luijckx, Gert-Jan [1 ]
Vroomen, Patrick C. A. J. [1 ]
van der Zee, Durk-Jouke [2 ]
Buskens, Erik [3 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands
[2] Univ Groningen, Dept Operat, Fac Econ & Business, Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
关键词
acute stroke; implementation; organizational model; thrombolysis; TISSUE-PLASMINOGEN ACTIVATOR; ACUTE ISCHEMIC-STROKE; ALTEPLASE; NATIONWIDE; CENTERS; OLDER;
D O I
10.1161/STROKEAHA.111.641795
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-Today, treatment of acute stroke consists of tissue-type plasminogen activator (tPA), admission to a stroke unit, and aspirin. Although tPA treatment is the most effective, there is substantial undertreatment. Centralized care may affect rate, timing, and outcome of thrombolysis compared to decentralized treatment in community hospitals. The present study aimed to assess the impact of organizational models on the proportion of patients undergoing tPA treatment. Methods-A prospective, multicenter, observational study among 13 hospitals in the North of the Netherlands was conducted. In the centralized model, tPA treatment for 4 hospitals was administered in 1 stroke center. The decentralized model comprised 9 community hospitals. Primary outcome was the proportion of patients treated with tPA. Secondary outcome measures were proportion of patients arriving within 4.5 hours, safety, 90-day functional outcome, and onset-to-door, door-to-needle, and onset-to-needle times. Potential confounders were adjusted using logistic regression analysis. Results-Two hundred eighty-three and 801 ischemic stroke patients were enrolled in the centralized and decentralized settings. Numbers of patients treated with tPA were 62 (21.9%) and 113 (14.1%) (OR, 1.72; 95% CI, 1.22-2.43). Adjusting for potential confounders did not alter results (OR, 2.03; 95% CI, 1.39-2.96). In the centralized setting, significantly more patients arrived at the hospital within the 4.5-hour time window (P < 0.01), and shorter door-to-needle times were reached (35 versus 47 minutes). Other secondary outcome measures did not differ across setting. Conclusions-In a centralized setting, the results demonstrate a 50% increased likelihood of treatment. Prehospital factors seem to contribute to this result. (Stroke. 2012;43:1336-1340.)
引用
收藏
页码:1336 / 1340
页数:5
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