Donor Characteristics Affecting Graft Failure, Graft-versus-Host Disease, and Survival after Unrelated Donor Transplantation with Reduced-Intensity Conditioning for Hematologic Malignancies

被引：23

作者：

Passweg, Jakob R. ^{[2
]}

Zhang, Mei-Jie ^{[1
]}

Rocha, Vanderson ^{[3
]}

Kan, Fangyu ^{[4
]}

Champlin, Richard E. ^{[5
]}

Isola, Luis M. ^{[6
]}

Gee, Adrian P. ^{[7
]}

Gibson, John ^{[8
]}

Laughlin, Mary J. ^{[9
]}

Lazarus, Hillard M. ^{[10
]}

Loren, Alison ^{[11
]}

Marks, David. ^{[12
]}

Gratwohl, Alois ^{[2
]}

Eapen, Mary ^{[1
]}

机构：

[1] Med Coll Wisconsin, Milwaukee, WI 54336 USA

[2] Univ Basel Hosp, CH-4031 Basel, Switzerland

[3] Hop St Louis, Paris, France

[4] Natl Marrow Donor Program, Minneapolis, MN USA

[5] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[6] Mt Sinai Med Ctr, New York, NY 10029 USA

[7] Baylor Coll Med, Houston, TX 77030 USA

[8] Royal Prince Alfred Hosp, Camperdown, NSW 2050, Australia

[9] Univ Virginia Hlth Syst, Charlottesville, VA USA

[10] Univ Hosp Case Med Ctr, Cleveland, OH USA

[11] Hosp Univ Penn, Philadelphia, PA 19104 USA

[12] United Bristol Healthcare Trust, Bristol, Avon, England

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2011年 / 17卷 / 12期

关键词：

Reduced-intensity conditioning regimen; Unrelated donor transplantation; Leukemias; STEM-CELL TRANSPLANTATION; RECIPIENTS; MARROW; LEUKEMIA;

D O I：

10.1016/j.bbmt.2011.07.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the effect of donor characteristics on graft failure (<5% donor chimerism within 3 months after transplantation), acute and chronic graft-versus-host disease (aGVHD, cGVHD), and survival after unrelated donor reduced-intensity conditioning (RIC) transplantation in 709 patients with hematologic malignancies. Donor recipient pairs were HLA typed at HLA-A, -B, -C, and -DRBI (allele-level). A total of 501 patients were >95% donor chimerism, 145 patients were 5% to 95%, and 63 patients were <5%. The only donor characteristic associated with transplantation outcome was donor recipient HLA matching. One- or 2-loci mismatched transplants led to higher grade 2-4 (relative risk [RR] = 1.27, P =.035) and grade 3-4 (RR = 1.85, P <.001) aGVHD and 2-loci mismatched transplants higher mortality (RR = 2.22, P <.001). Graft failure was higher after transplantation of bone marrow (RR = 2.33, P =.002). Donor age, parity, and donor sex match were not associated with transplantation outcome. Donor recipient HLA matching is the only donor characteristic predictive for survival after RIC regimens for hematologic malignancies. Biol Blood Marrow Transplant 17: 1869-1873 (2011) (C) 2011 American Society for Blood and Marrow Transplantation

引用

页码：1869 / 1873

页数：5

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