Peripheral Blood Derived Cell Trafficking for Cardiac Regeneration

被引：1
作者：
Post, Simone [1 ,3 ]
Goumans, Marie-Jose [1 ,2 ]
Doevendans, Pieter A. [1 ,3 ]
机构：
[1] UMCU, Div Heart & Lungs, Lab Expt Cardiol, NL-3584 CX Utrecht, Netherlands
[2] Leiden Univ, Dept Mol Cell Biol, Med Ctr, Leiden, Netherlands
[3] Interunivers Cardiol Inst, Utrecht, Netherlands
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2010年 / 5卷 / 04期
关键词：
Blood cells; cytokines; homing; left ventricular ejection fraction; mobilization; myocardial infarction; ENDOTHELIAL PROGENITOR CELLS; MESENCHYMAL STEM-CELLS; COLONY-STIMULATING FACTOR; ACUTE MYOCARDIAL-INFARCTION; REDUCED NEOVASCULARIZATION CAPACITY; VENTRICULAR EJECTION FRACTION; BONE-MARROW; HEMATOPOIETIC STEM; MONONUCLEAR-CELLS; CD34(+) CELLS;
D O I：
10.2174/157488810793351712
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Systemic available circulating cells play a role in cardiac maintenance and ameliorate cardiac recovery and repair after myocardial infarction. However, only a small number of cells will be incorporated during cardiac damage. Cell mobilization, homing to the ischemic myocardium and engraftment are complex processes depending on many adhesion molecules, proteases, chemokines and their receptors. Physiologic and pathophysiologic circumstances, cytokines, chemokines and certain drugs are able to influence these processes. For cardiovascular regeneration, understanding how mobilization and homing of blood derived cells is regulated and can be modulated as well as identification of cell populations able to regenerate the heart or reduce damage after myocardial infarction is essential for the development of successful cell based therapies.
引用
收藏
页码：303 / 313
页数：11
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