Inhibitors of signal transduction: The alkylphosphocholines

被引：0

作者：

Hilgard, F ^{[1
]}

Klenner, T ^{[1
]}

Engel, J ^{[1
]}

机构：

[1] ASTA Med AG, Expt Canc Res, D-60001 Frankfurt, Germany

来源：

DRUG NEWS & PERSPECTIVES | 1999年 / 12卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The experimental antitumor activity of the alkylphosphocholines, a new class of signal transduction inhibitors, has been demonstrated repeatedly. The alkylphosphocholines have inhibitory activities on protein kinase C (PKC) and phospholipase C. The PKC pathway of signal transduction may be involved in cellular differentiation and in the induction of apoptosis. Moreover, PKC inhibition by miltefosine may affect tumor invasion and metastasis formation. Miltefosine may also interfere with immunological mechanisms. Finally, in addition to its antitumor activity, miltefosine also exerts substantial effects on a number of Leishmania strains. In brief, miltefosine and other alkylphosphocholines interact with signal transduction components of cellular functions such as differentiation, growth control, migration, tumor promotion and cell death. Due to these activities, this new class of pharmacophores has a great potential in the treatment of cancer and certain parasitic diseases. (C) 1999 Prous Science. All rights reserved.

引用

页码：69 / 72

页数：4

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[1] The development of alkylphosphocholines as signal transduction inhibitors: experimental and clinical challenges [J].

P. Hilgard ;

J. Pohl ;

J. Engel .

Journal of Cancer Research and Clinical Oncology, 1997, 123 :286-287

[2] The development of alkylphosphocholines as signal transduction inhibitors: Experimental and clinical challenges [J].

Hilgard, P ;

Pohl, J ;

Engel, J .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1997, 123 (05) :286-287

[3] Inhibitors of cytokine signal transduction [J].

Wormald, S ;

Hilton, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (02) :821-824

[4] SIGNAL-TRANSDUCTION INHIBITORS [J].

GRUNICKE, H .

EUROPEAN JOURNAL OF CANCER, 1995, 31A (05) :833-834

[5] Inhibitors of the Hedgehog Signal Transduction Pathway [J].

Robbins, David J. ;

Goetz, John A. ;

Yuan, Ziqiang ;

Stegman, Melanie A. .

CURRENT CANCER THERAPY REVIEWS, 2005, 1 (03) :277-288

[6] Signal transduction inhibitors - a work in progress [J].

Becker, J .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :15-18

[7] Signal transduction inhibitors—a work in progress [J].

Joseph Becker .

Nature Biotechnology, 2004, 22 :15-18

[8] Inhibitors of bacterial signal transduction kinase [J].

Lloyd, AW .

DRUG DISCOVERY TODAY, 2000, 5 (08) :376-376

[9] Inhibitors of Brassinosteroid Biosynthesis and Signal Transduction [J].

Rozhon, Wilfried ;

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Fernandez, Atiara ;

Poppenberger, Brigitte .

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[10] Signal transduction inhibitors from microorganisms [J].

Wrigley, SK ;

Kau, DA ;

Waters, B ;

Davies, JE .

BIODIVERSITY: NEW LEADS FOR THE PHARMACEUTICAL AND AGROCHEMICAL INDUSTRIES, 2000, (257) :86-99

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