Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

被引：25

作者：

Hwang, MH

Lim, JH

Yun, HI

Rhee, MH

Cho, JY

Hsu, W

Park, SC ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacol & Toxicol, Taegu 702701, South Korea

[2] Chungnam Natl Univ, Coll Vet Med, Taejon 302305, South Korea

[3] Kangwon Natl Univ, Sch Biotechnol & Bioengn, Chunchon 200701, South Korea

[4] Iowa State Univ, Dept Biomed Sci, Ames, IA 50011 USA

来源：

BIOTECHNOLOGY LETTERS | 2005年 / 27卷 / 20期

关键词：

cytokine; cyclooxygenase; interleukin-1; beta; nitric oxide; surfactin;

D O I：

10.1007/s10529-005-2515-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 mu g ml(-1))-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1 beta and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 mu g ml(-1) inhibited the LPS-induced increase in the transcription of IL-1 beta and iNOS and nitric oxide (NO) production in a dose-dependent manner.

引用

页码：1605 / 1608

页数：4

共 12 条

[1] SURFACTIN A CRYSTALLINE PEPTIDELIPID SURFACTANT PRODUCED BY BACILLUS SUBTILIS - ISOLATION CHARACTERIZATION AND ITS INHIBITION OF FIBRIN CLOT FORMATION [J].