MicroRNAs in metabolism and metabolic disorders

被引：930

作者：

Rottiers, Veerle ^{[1
,2
]}

Naeaer, Anders M. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

SUBCUTANEOUS ADIPOSE-TISSUE; HEPATIC LIPID-METABOLISM; ELEMENT-BINDING PROTEIN; FATTY-ACID-METABOLISM; PANCREATIC BETA-CELLS; GENE-EXPRESSION; ADIPOCYTE DIFFERENTIATION; GLUCOSE-METABOLISM; IN-VIVO; CHOLESTEROL HOMEOSTASIS;

D O I：

10.1038/nrm3313

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. The discovery of circulating miRNAs has highlighted their potential as both endocrine signalling molecules and disease markers. Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that miRNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.

引用

页码：239 / 250

页数：12

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