Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study

被引：122

作者：

Lim, Yen Ying ^{[1
,2
]}

Ellis, Kathryn A. ^{[1
,2
]}

Harrington, Karra ^{[1
]}

Ames, David ^{[2
,3
]}

Martins, Ralph N. ^{[4
]}

Masters, Colin L. ^{[1
,5
]}

Rowe, Christopher ^{[6
]}

Savage, Greg ^{[7
,8
]}

Szoeke, Cassandra ^{[9
]}

Darby, David ^{[1
,5
,10
,11
]}

Maruff, Paul ^{[5
,10
]}

机构：

[1] Univ Melbourne, Mental Hlth Res Inst, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia

[3] Natl Aging Res Inst, Parkville, Vic, Australia

[4] Edith Cowan Univ, Ctr Excellence Alzheimers Dis Res & Care, Sch Exercise Biomed & Hlth Sci, Perth, WA, Australia

[5] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia

[6] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia

[7] Macquarie Univ, Dept Psychol, Sydney, NSW 2109, Australia

[8] Macquarie Univ, ARC Ctr Excellence Cognit & Its Disorders, Sydney, NSW 2109, Australia

[9] CSIRO, Preventat Hlth Flagship, Parkville, Vic, Australia

[10] CogState Ltd, Melbourne, Vic, Australia

[11] Florey Neurosci Inst, Carlton, Vic, Australia

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY | 2012年 / 34卷 / 04期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; CogState; Australian Imaging; Biomarkers and Lifestyle study; Apolipoprotein E epsilon 4; Cognitive testing; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; MEMORY DECLINE; CORONARY SURGERY; WORKING-MEMORY; APOE GENOTYPE; OLDER-PEOPLE; DEMENTIA; AGE;

D O I：

10.1080/13803395.2011.643227

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

The aim of this study was to validate the CogState Brief Battery, which assesses psychomotor, attentional, working memory, and visual learning functions, in healthy older people and in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. In healthy older adults, weak relationships between demographic variables (e. g., education, depression) and cognitive performance were observed. In AD and MCI groups, the magnitude of impairment was greatest for tasks of working memory and memory, with a negative influence of apolipoprotein E epsilon 4 status on learning but not working memory. These results suggest that the CogState Brief Battery can be used to screen for AD-related cognitive changes.

引用

页码：345 / 358

页数：14

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