Medulloblastoma and Down Syndrome: An Extremely Rare Association

被引：2

作者：

Baroni, Lorena, V ^{[1
]}

Cassina, Tamara Munoz ^{[1
]}

Ponce, Nicolas Fernandez ^{[1
]}

Pinto, Natalia ^{[2
]}

Vazquez, Valeria ^{[3
]}

Lubieniecki, Fabiana ^{[3
]}

Alderete, Daniel ^{[1
]}

机构：

[1] Hosp JP Garrahan, Serv Hematol Oncol, 1881 Combate Pozos St, RA-1245 Buenos Aires, DF, Argentina

[2] Hosp JP Garrahan, Serv Radiotherapy, Buenos Aires, DF, Argentina

[3] Hosp JP Garrahan, Serv Pathol, Buenos Aires, DF, Argentina

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2022年 / 44卷 / 07期

关键词：

Down syndrome; medulloblastoma; SHH; brain tumor; CHILDREN;

D O I：

10.1097/MPH.0000000000002448

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Medulloblastoma has a reduced incidence in Down syndrome (DS). This protective characteristic has not been clarified yet. Here, we report the second case of SHH medulloblastoma and DS documented in the literature. A complete surgery was performed followed by reduced craniospinal irradiation dose and adjuvant chemotherapy. No evidence of tumor recurrence was observed. The overall survival was 9.1 years. No family history or physical stigma of other hereditary predisposition syndrome was found. In the elucidation of this extremely rare association, future case reports play an important role in defining the spectrum of brain tumors and their peculiar features in DS.

引用

页码：415 / 418

页数：4

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