Cu-Catalyzed C-H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates

被引:21
作者
Li, Jian-Jun [1 ]
Wang, Cheng-Gang [1 ]
Yu, Jin-Feng [1 ]
Wang, Peng [1 ,2 ]
Yu, Jin-Quan [3 ]
机构
[1] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Ctr Excellence Mol Synth, Shanghai 200032, Peoples R China
[2] Shanghai Inst Organ Chem, CAS Key Lab Energy Regulat Mat, Shanghai 200032, Peoples R China
[3] Scripps Res Inst, La Jolla, CA 92037 USA
基金
中国国家自然科学基金;
关键词
FUNCTIONALIZATION; PALLADIUM; ARYLATION; BONDS; OLEFINATION; ARYL; ARENES; AMIDATION; AMINATION; ESTERS;
D O I
10.1021/acs.orglett.0c01469
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient Cu-catalyzed C-H alkenylation with acyclic and cyclic vinyl boronates was realized for the first time under mild conditions. The scope of the vinyl borons and the compatibility with functional groups including heterocycles are superior than Pd-catalyzed C-H coupling with vinyl borons, providing a reliable access to multisubstituted alkenes and dienes. Subsequent hydrogenation of the product from the internal vinyl borons will lead to installation of secondary alkyls.
引用
收藏
页码:4692 / 4696
页数:5
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