Wolbachia Enhance Drosophila Stem Cell Proliferation and Target the Germline Stem Cell Niche

被引：141

作者：

Fast, Eva M. ^{[1
]}

Toomey, Michelle E. ^{[1
,2
]}

Panaram, Kanchana ^{[1
]}

Desjardins, Danielle ^{[1
]}

Kolaczyk, Eric D. ^{[3
]}

Frydman, Horacio M. ^{[1
,2
]}

机构：

[1] Boston Univ, Dept Biol, Boston, MA 02215 USA

[2] Boston Univ, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA

[3] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA

来源：

SCIENCE | 2011年 / 334卷 / 6058期

关键词：

LIFE-SHORTENING WOLBACHIA; AEDES-AEGYPTI; RAPID SPREAD; INFECTION; INCOMPATIBILITY; MELANOGASTER; SIMULANS; BIOLOGY; FUSOME; DEATH;

D O I：

10.1126/science.1209609

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wolbachia are widespread maternally transmitted intracellular bacteria that infect most insect species and are able to alter the reproduction of innumerous hosts. The cellular bases of these alterations remain largely unknown. Here, we report that Drosophila mauritiana infected with a native Wolbachia wMau strain produces about four times more eggs than the noninfected counterpart. Wolbachia infection leads to an increase in the mitotic activity of germline stem cells (GSCs), as well as a decrease in programmed cell death in the germarium. Our results suggest that up-regulation of GSC division is mediated by a tropism of Wolbachia for the GSC niche, the cellular microenvironment that supports GSCs.

引用

页码：990 / 992

页数：4

共 30 条

[1] Wolbachia surface protein (WSP) inhibits apoptosis in human neutrophils [J].