Potential anti-inflammatory diterpenes from Premna obrusifolia

被引：32

作者：

Salae, Abdul-Wahab ^{[1
]}

Rodjun, Apinya ^{[1
]}

Karalai, Chatchanok ^{[1
,2
]}

Ponglimanont, Chanita ^{[1
]}

Chantrapromma, Suchada ^{[1
,2
]}

Kanjana-Opas, Akkharawit ^{[3
]}

Tewtrakul, Supinya ^{[4
]}

Fun, Hoong-Kun ^{[5
]}

机构：

[1] Prince Songkla Univ, Fac Sci, Ctr Innovat Chem, Hat Yai 90112, Songkhla, Thailand

[2] Prince Songkla Univ, Fac Sci, Dept Chem, Crystal Mat Res Unit, Hat Yai 90112, Songkhla, Thailand

[3] Prince Songkla Univ, Fac Agroind, Dept Ind Biotechnol, Hat Yai 90112, Songkhla, Thailand

[4] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai 90112, Songkhla, Thailand

[5] Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, Usm 11800, Penang, Malaysia

来源：

TETRAHEDRON | 2012年 / 68卷 / 03期

关键词：

Premna obtusifolia; Diterpene; Sesquiterpene; Obtusinone A; B; and C; Antibacterial activity; Anti-inflammatory activity; LEAVES; ROOTS; ANTIBACTERIAL; ABIETANE; SESQUITERPENE; CONSTITUENTS; TERPENOIDS;

D O I：

10.1016/j.tet.2011.11.058

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Eleven new diterpenoids: pimaranes (1,2), rosanes (3) abietanes (4-7), icetexanes (8), and rearranged icetexanes (9-11), together with fifteen known diterpenes (12-26) and two known sesquiterpenes (27,28) have been isolated from the roots and twigs of Premna obtusifolia. The structures of these compounds were elucidated on the basis of spectroscopic analysis and X-ray crystallographic data of 8 and 9 were also determined. The antibacterial and anti-inflammatory activities of the isolates were evaluated. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：819 / 829

页数：11

共 47 条

[1]

Banskota AH, 2003, PLANTA MED, V69, P500, DOI 10.1055/s-2003-40641

[2] Antibacterial and cytotoxic xanthones from the roots of Cratoxylum formosum [J].

Boonsri, S ;

Karalai, C ;

Ponglimanont, C ;

Kanjana-opas, A ;

Chantrapromma, K .

PHYTOCHEMISTRY, 2006, 67 (07) :723-727

[3]

*BRUK AXS, 2005, APEX2 VERS 1 27 SAIN

[4]

CAMPELLO JD, 1975, PHYTOCHEMISTRY, V14, P243

[5] Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa [J].

Chin, Young-Won ;

Jones, William P. ;

Mi, Qiuwen ;

Rachman, Ismail ;

Riswan, Soedarsono ;

Kardono, Leonardus B. S. ;

Chai, Hee-Byung ;

Farnsworth, Norman R. ;

Cordell, Geoffrey A. ;

Swanson, Steven M. ;

Cassady, John M. ;

Kinghorn, A. Douglas .

PHYTOCHEMISTRY, 2006, 67 (12) :1243-1248

[6] THE APPLICATION OF VACUUM LIQUID-CHROMATOGRAPHY TO THE SEPARATION OF TERPENE MIXTURES [J].

COLL, JC ;

BOWDEN, BF .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (05) :934-936

[7] Diterpenes from Erythroxylum barbatum [J].

dos Santos, Claudio C. ;

Lima, Mary Anne S. ;

Braz Filho, Raimundo ;

Silveira, Edilberto R. .

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2006, 17 (07) :1304-1308

[8] ABIETANE AND ICETEXANE DITERPENOIDS FROM THE ROOTS OF SALVIA-ASPERA [J].

ESQUIVEL, B ;

FLORES, M ;

HERNANDEZORTEGA, S ;

TOSCANO, RA ;

RAMAMOORTHY, TP .

PHYTOCHEMISTRY, 1995, 39 (01) :139-143

[9] Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity [J].

Fraga, BM ;

Díaz, CE ;

Guadaño, A ;

González-Coloma, A .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (13) :5200-5206

[10] Sesqui- and diterpenes from the liverwort Gackstroemia decipiens [J].

Geis, W ;

Becker, H .

PHYTOCHEMISTRY, 2000, 53 (02) :247-252

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