A dopamine D1 agonist elevates self-stimulation thresholds:: Comparison to other dopamine-selective drugs

被引:26
作者
Baldo, BA
Jain, K
Veraldi, L
Koob, GF
Markou, A
机构
[1] Scripps Res Inst, Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, Sch Med, Dept Neurosci, Program Neurosci, La Jolla, CA 92093 USA
关键词
brain stimulation reward; response latency; dopamine; SKF81297; 7-OH-DPAT; SCH23390; raclopride; GBR12909;
D O I
10.1016/S0091-3057(98)00206-8
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of the high-efficacy D-1 receptor agonist SKF 81297 and the D-2/3 receptor agonist 7-OH-DPAT on brain stimulation reward thresholds and on response latencies in responding for the stimulation, were compared to the effects of subtype-selective receptor antagonists and a dopamine uptake blocker. SKF 81297 produced dose-dependent elevations in reward thresholds but did not alter response latencies. In contrast, 7-OH-DPAT produced inconsistent reward threshold elevations, yet dose dependently increased response latencies. Both the dopamine D1 receptor antagonist SCH 23390 and the D-2 antagonist raclopride elevated reward thresholds, but only raclopride significantly increased response latencies. The dopamine uptake inhibitor GBR 12909 lowered reward thresholds and did not influence response latencies. The present results provide a clear demonstration that a selective, high-efficacy D-1 receptor agonist elevates brain stimulation reward thresholds without producing performance deficits. Furthermore, it was observed that the effects upon reward measures of D-1-selective compounds, but not D-2/D-3-selective compounds, are dissociable from their effects upon response latency in this task. These results are discussed with regard to a distinction between the effects of indirect and direct dopamine agonists on reward thresholds, a distinction that does not depend upon the subtype-selectivity of the direct agonists tested. (C) 1999 Elsevier Science Inc.
引用
收藏
页码:659 / 672
页数:14
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