Pancreatic cancer

被引：2451

作者：

Vincent, Audrey ^{[1
]}

Herman, Joseph ^{[5
]}

Schulick, Rich ^{[3
]}

Hruban, Ralph H. ^{[1
,2
]}

Goggins, Michael ^{[1
,2
,4
]}

机构：

[1] Johns Hopkins Univ, Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Pathol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Oncol, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Surg, Baltimore, MD 21231 USA

[4] Johns Hopkins Univ, Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Med, Baltimore, MD 21231 USA

[5] Johns Hopkins Univ, Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Radiat Oncol, Baltimore, MD 21231 USA

来源：

LANCET | 2011年 / 378卷 / 9791期

关键词：

PHASE-III TRIAL; GEMCITABINE-BASED CHEMORADIATION; PAPILLARY MUCINOUS NEOPLASMS; DNA METHYLATION ALTERATIONS; GENOME-WIDE ASSOCIATION; FINE-NEEDLE-ASPIRATION; HIGH-RISK INDIVIDUALS; DUCTAL ADENOCARCINOMA; FAMILY-HISTORY; RESECTABLE ADENOCARCINOMA;

D O I：

10.1016/S0140-6736(10)62307-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant disease. The incidence of and number of deaths caused by pancreatic tumours have been gradually rising, even as incidence and mortality of other common cancers have been declining. Despite developments in detection and management of pancreatic cancer, only about 4% of patients will live 5 years after diagnosis. Survival is better for those with malignant disease localised to the pancreas, because surgical resection at present offers the only chance of cure. Unfortunately, 80-85% of patients present with advanced unresectable disease. Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanisms that contribute to development and progression of pancreatic tumours. In this Seminar we will discuss the most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinoma.

引用

页码：607 / 620

页数：14

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