Equine recurrent uveitis - A spontaneous horse model of uveitis

被引：69

作者：

Deeg, Cornelia A. ^{[1
]}

Hauck, Stefanie M. ^{[3
]}

Amann, Barbara ^{[1
]}

Pompetzki, Dirk ^{[1
]}

Altmann, Frank ^{[1
]}

Raith, Albert ^{[1
]}

Schmalzl, Thomas ^{[1
]}

Stangassinger, Manfred ^{[1
]}

Ueffing, Marius ^{[2
,3
]}

机构：

[1] Univ Munich, Inst Anim Physiol, DE-80539 Munich, Germany

[2] Tech Univ Munich, Inst Human Genet, Munich, Germany

[3] Helmholtz Ctr Environm & Hlth, Inst Human Genet, Neuherberg, Germany

来源：

OPHTHALMIC RESEARCH | 2008年 / 40卷 / 3-4期

关键词：

uveitis; spontaneous model; horse; autoimmune; target organ; autoantigens; proteomics; regulated proteins;

D O I：

10.1159/000119867

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody-binding pattern of horses affected by spontaneous recurrent uveitis (ERU) to the retinal proteome. CRALBP also seems to be relevant to human autoimmune uveitis. Proteomic screening of vitreous and retinal samples from ERU diseased cases in comparison to healthy controls has led to the identification of a series of differentially regulated proteins, which are functionally linked to the immune system and the maintenance of the blood-retinal barrier. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：151 / 153

页数：3

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