High incidence of IDH mutations in acute myeloid leukaemia with cuplike nuclei

被引：14

作者：

Rakheja, Dinesh ^{[1
,2
]}

Konoplev, Sergej ^{[3
]}

Su, Mu ^{[1
]}

Wheeler, David ^{[4
]}

Muzny, Donna M. ^{[4
]}

Ruvolo, Vivian R. ^{[5
]}

Collins, Robert ^{[6
]}

Karandikar, Nitin J. ^{[1
]}

Andreeff, Michael ^{[5
]}

Medeiros, Leonard Jeffrey ^{[3
]}

Chen, Weina ^{[1
,7
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

[2] Childrens Med Ctr, Dept Pathol, Dallas, TX 75235 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Leukaemia, Houston, TX 77030 USA

[6] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[7] Ameripath Quest Diagnost, Dallas, TX USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2011年 / 155卷 / 01期

关键词：

acute leukaemia; acute myeloid leukaemia; cuplike; IDH; NPM1; FLT3; INTERNAL TANDEM DUPLICATION; NPM1; MUTATION;

D O I：

10.1111/j.1365-2141.2011.08646.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：125 / 128

页数：5

共 10 条

[1] Cuplike Nuclei (Prominent Nuclear Invaginations) in Acute Myeloid Leukemia Are Highly Associated With FLT3 Internal Tandem Duplication and NPM1 Mutation [J].

Chen, Weina ;

Konoplev, Sergej ;

Medeiros, L. Jeffrey ;

Koeppen, Hartmut ;

Leventaki, Vasiliki ;

Vadhan-Raj, Saroj ;

Jones, Dan ;

Kantarjian, Hagop M. ;

Falini, Brunangelo ;

Bueso-Ramos, Carlos E. .

CANCER, 2009, 115 (23) :5481-5489

[2] Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation [J].

Figueroa, Maria E. ;

Abdel-Wahab, Omar ;

Lu, Chao ;

Ward, Patrick S. ;

Patel, Jay ;

Shih, Alan ;

Li, Yushan ;

Bhagwat, Neha ;

Vasanthakumar, Aparna ;

Fernandez, Hugo F. ;

Tallman, Martin S. ;

Sun, Zhuoxin ;

Wolniak, Kristy ;

Peeters, Justine K. ;

Liu, Wei ;

Choe, Sung E. ;

Fantin, Valeria R. ;

Paietta, Elisabeth ;

Lowenberg, Bob ;

Licht, Jonathan D. ;

Godley, Lucy A. ;

Delwel, Ruud ;

Valk, Peter J. M. ;

Thompson, Craig B. ;

Levine, Ross L. ;

Melnick, An .

CANCER CELL, 2010, 18 (06) :553-567

[3] Cup-like acute myeloid leukemia: new disease or artificial phenomenon? [J].

Kroschinsky, Frank P. ;

Schaekel, Ulrike ;

Fischer, Rainer ;

Mohr, Brigitte ;

Oelschlaegel, Uta ;

Repp, Roland ;

Schaich, Markus ;

Soucek, Silke ;

Baretton, Gustavo ;

Ehninger, Gerhard ;

Thiede, Christian .

HAEMATOLOGICA, 2008, 93 (02) :283-286

[4] IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study [J].

Marcucci, Guido ;

Maharry, Kati ;

Wu, Yue-Zhong ;

Radmacher, Michael D. ;

Mrozek, Krzysztof ;

Margeson, Dean ;

Holland, Kelsi B. ;

Whitman, Susan P. ;

Becker, Heiko ;

Schwind, Sebastian ;

Metzeler, Klaus H. ;

Powell, Bayard L. ;

Carter, Thomas H. ;

Kolitz, Jonathan E. ;

Wetzler, Meir ;

Carroll, Andrew J. ;

Baer, Maria R. ;

Caligiuri, Michael A. ;

Larson, Richard A. ;

Bloomfield, Clara D. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (14) :2348-2355

[5] IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication [J].

Paschka, Peter ;

Schlenk, Richard F. ;

Gaidzik, Verena I. ;

Habdank, Marianne ;

Kroenke, Jan ;

Bullinger, Lars ;

Spaeth, Daniela ;

Kayser, Sabine ;

Zucknick, Manuela ;

Goetze, Katharina ;

Horst, Heinz-A. ;

Germing, Ulrich ;

Doehner, Hartmut ;

Doehner, Konstanze .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (22) :3636-3643

[6] Isocitrate Dehydrogenase 1/2 Mutational Analyses and 2-Hydroxyglutarate Measurements in Wilms Tumors [J].

Rakheja, Dinesh ;

Mitui, Midori ;

Boriack, Richard L. ;

DeBerardinis, Ralph J. .

PEDIATRIC BLOOD & CANCER, 2011, 56 (03) :379-383

[7] IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group [J].

van den Bent, Martin J. ;

Dubbink, Hendrikus J. ;

Marie, Yannick ;

Brandes, Alba A. ;

Taphoorn, Martin J. B. ;

Wesseling, Pieter ;

Frenay, Marc ;

Tijssen, Cees C. ;

Lacombe, Denis ;

Idbaih, Ahmed ;

van Marion, Ronald ;

Kros, Johan M. ;

Dinjens, Winand N. M. ;

Gorlia, Thierry ;

Sanson, Marc .

CLINICAL CANCER RESEARCH, 2010, 16 (05) :1597-1604

[8] The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate [J].

Ward, Patrick S. ;

Patel, Jay ;

Wise, David R. ;

Abdel-Wahab, Omar ;

Bennett, Bryson D. ;

Coller, Hilary A. ;

Cross, Justin R. ;

Fantin, Valeria R. ;

Hedvat, Cyrus V. ;

Perl, Alexander E. ;

Rabinowitz, Joshua D. ;

Carroll, Martin ;

Su, Shinsan M. ;

Sharp, Kim A. ;

Levine, Ross L. ;

Thompson, Craig B. .

CANCER CELL, 2010, 17 (03) :225-234

[9] Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases [J].

Xu, Wei ;

Yang, Hui ;

Liu, Ying ;

Yang, Ying ;

Wang, Ping ;

Kim, Se-Hee ;

Ito, Shinsuke ;

Yang, Chen ;

Wang, Pu ;

Xiao, Meng-Tao ;

Liu, Li-xia ;

Jiang, Wen-qing ;

Liu, Jing ;

Zhang, Jin-ye ;

Wang, Bin ;

Frye, Stephen ;

Zhang, Yi ;

Xu, Yan-hui ;

Lei, Qun-ying ;

Guan, Kun-Liang ;

Zhao, Shi-min ;

Xiong, Yue .

CANCER CELL, 2011, 19 (01) :17-30

[10] IDH1 and IDH2 Mutations in Gliomas [J].

Yan, Hai ;

Parsons, D. Williams ;

Jin, Genglin ;

McLendon, Roger ;

Rasheed, B. Ahmed ;

Yuan, Weishi ;

Kos, Ivan ;

Batinic-Haberle, Ines ;

Jones, Sian ;

Riggins, Gregory J. ;

Friedman, Henry ;

Friedman, Allan ;

Reardon, David ;

Herndon, James ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Vogelstein, Bert ;

Bigner, Darell D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (08) :765-773

← 1 →