Extending the Neuroanatomic Territory of Diffuse Midline Glioma, K27M Mutant: Pineal Region Origin

被引：13

作者：

Gilbert, Andrea R. ^{[1
,4
]}

Zaky, Wafik ^{[2
]}

Gokden, Murat ^{[5
]}

Fuller, Christine E. ^{[6
]}

Ocal, Eylem ^{[7
,8
]}

Leeds, Norman E. ^{[3
]}

Fuller, Gregory N. ^{[4
]}

机构：

[1] Houston Methodist Hosp, Dept Pathol Lab Med, Houston, TX USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Pediat Patient Care, Div Pediat, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Sect Neuroradiol, Dept Diagnost Radiol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Sect Neuropathol, Houston, TX 77030 USA

[5] Univ Arkansas Med Sci, Div Neuropathol, Dept Pathol, Little Rock, AR 72205 USA

[6] Cincinnati Childrens Hosp Med Ctr, Dept Pathol & Lab Med, Cincinnati, OH 45229 USA

[7] Univ Arkansas Med Sci, Dept Neurosurg, Little Rock, AR 72205 USA

[8] Arkansas Childrens Hosp, 800 Marshall St, Little Rock, AR 72202 USA

来源：

PEDIATRIC NEUROSURGERY | 2018年 / 53卷 / 01期

关键词：

Pineal tumor; Diffuse midline glioma; H3-K27M mutant; INTRINSIC PONTINE GLIOMA; HIGH-GRADE GLIOMAS; HISTONE H3.3; MUTATIONS; H3F3A; GLIOBLASTOMA; INHIBITION; SUBGROUPS; CHILDREN; TARGETS;

D O I：

10.1159/000481513

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diffuse midline glioma, H3-K27M mutant (DMG-K27M) is a newly described, molecularly distinct infiltrative glioma that almost exclusively arises in midline CNS structures, including the brain stem, especially the pons, as well as the thalamus and spinal cord with rare examples seen in the cerebellum, third ventricle, and hypothalamus. To our knowledge, only 1 case of a molecularly confirmed DMG-K27M arising in the pineal region has been previously reported. We present the second occurrence of a tissue-confirmed DMG-K27M of the pineal region, which, to our knowledge, is the first case reported in a child and the first case with documented preoperative MRI. This case, in addition to a prior report described in an adult, defines the lower end of a broad age range of DMG-K27M onset (12-65 years) and establishes the pineal gland as a bona fide site of origin for this newly codified midline glioma. (C) 2017 S. Karger AG, Basel

引用

页码：59 / 63

页数：5

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