Embryonic asymmetry: The left side gets all the best genes

被引:16
作者
King, T [1 ]
Brown, NA [1 ]
机构
[1] St George Hosp, Sch Med, Dept Anat & Dev Biol, London SW17 0RE, England
关键词
D O I
10.1016/S0960-9822(99)80036-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The origin of left-right developmental asymmetry is a continuing puzzle, but some recent results provide new insights into the steps leading to organ asymmetry implicating the homeobox protein Pitz-2 in one key step - and others support a model of symmetry-breaking that involves the chirality of microtubules.
引用
收藏
页码:R18 / +
页数:6
相关论文
共 30 条
[1]   Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development [J].
Biben, C ;
Harvey, RP .
GENES & DEVELOPMENT, 1997, 11 (11) :1357-1369
[2]  
BROWN NA, 1990, DEVELOPMENT, V109, P1
[3]   Mutation of the mouse hepatocyte nuclear factor forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry [J].
Chen, JC ;
Knowles, HJ ;
Hebert, JL ;
Hackett, BP .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (06) :1077-1082
[4]  
Chen JN, 1997, DEVELOPMENT, V124, P4373
[5]  
Dufort D, 1998, DEVELOPMENT, V125, P3015
[6]  
Endow SA, 1998, BIOESSAYS, V20, P108, DOI 10.1002/(SICI)1521-1878(199802)20:2<108::AID-BIES2>3.0.CO
[7]  
2-P
[8]   Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1 [J].
Firulli, AB ;
McFadden, DG ;
Lin, Q ;
Srivastava, D ;
Olson, EN .
NATURE GENETICS, 1998, 18 (03) :266-270
[9]   X-linked situs abnormalities result from mutations in ZIC3 [J].
Gebbia, M ;
Ferrero, GB ;
Pilia, G ;
Bassi, MT ;
Aylsworth, AS ;
PenmanSplitt, M ;
Bird, LM ;
Bamforth, JS ;
Burn, J ;
Schlessinger, D ;
Nelson, DL ;
Casey, B .
NATURE GENETICS, 1997, 17 (03) :305-308
[10]   The left-right coordinator: The role of Vg1 in organizing left-right axis formation [J].
Hyatt, BA ;
Yost, HJ .
CELL, 1998, 93 (01) :37-46