Tumescent Liposuction: Partitioning of Lidocaine at a Lower Dose (252 mg/l)

被引:9
作者
Wang, Gang [1 ]
Cao, Weigang [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Shanghai 200011, Peoples R China
关键词
Tumescent liposuction; Lidocaine recovery; Lidocaine partitioning; MONOETHYLGLYCINEXYLIDIDE; ANESTHESIA; EFFICACY;
D O I
10.1159/000327382
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: The popularity of large-volume liposuction and the toxicity of lidocaine have led to a reduction of lidocaine dosage in tumescent liposuction. We have gradually reduced the concentration of lidocaine from 500 to 252 mg/l over the past decade. Objective: To evaluate the partitioning and the recovery of lidocaine at a lower concentration in tumescent liposuction. Methods: 10 consecutive patients' aspirate samples were analysed for the lidocaine concentration in the fat and the fluid component, the percentage of injected lidocaine removed by aspiration and its partition coefficient in fat versus fluid. Results: 7.5% of the injected lidocaine was removed; its partition coefficient was 0.21. Conclusion: 7.5% of the total lidocaine was aspirated in tumescent liposuction. The fat uptake of lidocaine was lower than in previous reports, which was of particular interest for future studies on lidocaine toxicity for the safety of the patients undergoing tumescent liposuction. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:274 / 277
页数:4
相关论文
共 9 条
  • [1] Tumescent Liposuction: Efficacy of a Lower Lidocaine Dose (400 mg/l)
    Boeni, Roland
    [J]. DERMATOLOGY, 2010, 220 (03) : 223 - 225
  • [2] Efficacy of tumescent local anesthesia with variable lidocaine concentration in 3430 consecutive cases of liposuction
    Habbema, Louis
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2010, 62 (06) : 988 - 994
  • [3] Fat partitioning of lidocaine in tumescent liposuction - Discussion
    Thomson, JG
    Hagerty, T
    [J]. ANNALS OF PLASTIC SURGERY, 1999, 42 (04) : 375 - 375
  • [4] Pharmacokinetics and safety of lidocaine and monoethylglycinexylidide in liposuction: A microdialysis study
    Kenkel, JM
    Lipschitz, AH
    Shepherd, G
    Armstrong, VW
    Streit, F
    Oellerich, M
    Luby, M
    Rohrich, RJ
    Brown, SA
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2004, 114 (02) : 516 - 524
  • [5] Klein JA., 1987, J Am Acad Cosmet Surg, V4, P263, DOI [DOI 10.1177/074880688700400403, 10.1177/074880688700400403]
  • [6] Prilocaine plasma levels and methemoglobinemia in patients undergoing tumescent liposuction involving less than 2,000 ml
    Lindenblatt, N
    Belusa, L
    Tiefenbach, B
    Schareck, W
    Olbrisch, RR
    [J]. AESTHETIC PLASTIC SURGERY, 2004, 28 (06) : 435 - 440
  • [7] Plasma lidocaine levels and risks after liposuction with tumescent anaesthesia
    Nordström, H
    Stånge, K
    [J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2005, 49 (10) : 1487 - 1490
  • [8] Hemodynamic Changes and Fluid Shifts After Large-Volume Fluid Infiltration Results From a Porcine Model
    Ozmen, Selahattin
    Kusza, Krzysztof
    Ulusal, Betul G.
    Pryor, Landon
    Siemionow, Maria
    Zins, James E.
    [J]. ANNALS OF PLASTIC SURGERY, 2010, 64 (01) : 83 - 88
  • [9] Streit F, 2001, CLIN CHEM, V47, P1853