Colorectal cancer screening in Lynch syndrome: Indication, techniques and future perspectives

被引:20
作者
Perrod, Guillaume [1 ,2 ]
Rahmi, Gabriel [1 ,2 ]
Cellier, Christophe [1 ,2 ]
机构
[1] Ctr Univ Paris, Georges Pompidou European Hosp, AP HP, Hepatogastroenterolgy & Digest Endoscopy Dept, 20 Rue Leblanc, F-75015 Paris, France
[2] Georges Pompidou European Hosp, PRED IdF Network, Paris, France
关键词
chromoendoscopy; colonosocpy screening; colorectal cancer; HNPCC; Lynch syndrome; COLONOSCOPIC SURVEILLANCE; GERMLINE MUTATIONS; MISS RATE; HEREDITARY; MANAGEMENT; ADENOMAS; MSH2; GUIDELINES; FAMILIES; MLH1;
D O I
10.1111/den.13702
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Lynch syndrome (LS) is an inherited predisposition to colorectal cancer (CRC), responsible for 3-5% of all CRC. This syndrome is characterized by the early occurrence of colorectal neoplastic lesions, with variable incidences depending on the type of pathogenic variants in MMR genes (MLH1, MSH2, MSH6, PMS2 and EPCAM) and demographics factors such as gender, body mass index, tobacco use and physical activity. Similar to sporadic cancers, colorectal screening by colonoscopy is efficient because it is associated with a reduction >50% of both CRC incidence and CRC related mortality. To that end, most guidelines recommend high definition screening colonoscopies in dedicated centers, starting at the age of 20-25 years old, with a surveillance interval of 1-2 years. In this review, we discuss the importance of high definition colonoscopies, including the compliance to specific key performance indicators, as well as the expected benefits of specific imaging modalities including virtual chromoendoscopy and dye-spray chromoendoscopy.
引用
收藏
页码:520 / 528
页数:9
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