Colorectal cancer screening in Lynch syndrome: Indication, techniques and future perspectives

被引:17
作者
Perrod, Guillaume [1 ,2 ]
Rahmi, Gabriel [1 ,2 ]
Cellier, Christophe [1 ,2 ]
机构
[1] Ctr Univ Paris, Georges Pompidou European Hosp, AP HP, Hepatogastroenterolgy & Digest Endoscopy Dept, 20 Rue Leblanc, F-75015 Paris, France
[2] Georges Pompidou European Hosp, PRED IdF Network, Paris, France
关键词
chromoendoscopy; colonosocpy screening; colorectal cancer; HNPCC; Lynch syndrome; COLONOSCOPIC SURVEILLANCE; GERMLINE MUTATIONS; MISS RATE; HEREDITARY; MANAGEMENT; ADENOMAS; MSH2; GUIDELINES; FAMILIES; MLH1;
D O I
10.1111/den.13702
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Lynch syndrome (LS) is an inherited predisposition to colorectal cancer (CRC), responsible for 3-5% of all CRC. This syndrome is characterized by the early occurrence of colorectal neoplastic lesions, with variable incidences depending on the type of pathogenic variants in MMR genes (MLH1, MSH2, MSH6, PMS2 and EPCAM) and demographics factors such as gender, body mass index, tobacco use and physical activity. Similar to sporadic cancers, colorectal screening by colonoscopy is efficient because it is associated with a reduction >50% of both CRC incidence and CRC related mortality. To that end, most guidelines recommend high definition screening colonoscopies in dedicated centers, starting at the age of 20-25 years old, with a surveillance interval of 1-2 years. In this review, we discuss the importance of high definition colonoscopies, including the compliance to specific key performance indicators, as well as the expected benefits of specific imaging modalities including virtual chromoendoscopy and dye-spray chromoendoscopy.
引用
收藏
页码:520 / 528
页数:9
相关论文
共 63 条
  • [1] Three molecular pathways model colorectal carcinogenesis in Lynch syndrome
    Ahadova, Aysel
    Gallon, Richard
    Gebert, Johannes
    Ballhausen, Alexej
    Endris, Volker
    Kirchner, Martina
    Stenzinger, Albrecht
    Burn, John
    Doeberitz, Magnus von Knebel
    Blaeker, Hendrik
    Kloor, Matthias
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2018, 143 (01) : 139 - 150
  • [2] Sessile serrated adenoma/polyp showed rapid malignant transformation in the final 13 months
    Amemori, Sadahiro
    Yamano, Hiro-o
    Tanaka, Yoshihito
    Yoshikawa, Kenjiro
    Matsushita, Hiro-o
    Takagi, Ryo
    Harada, Eiji
    Yoshida, Yuko
    Tsuda, Kazunori
    Kato, Bunichiro
    Tamura, Eri
    Eizuka, Makoto
    Sugai, Tamotsu
    Adachi, Yasushi
    Yamamoto, Eiichiro
    Suzuki, Hiromu
    Nakase, Hiroshi
    [J]. DIGESTIVE ENDOSCOPY, 2020, 32 (06) : 979 - 983
  • [3] Features of incident colorectal cancer in Lynch syndrome
    Argillander, Tanja E.
    Koornstra, Jan J.
    van Kouwen, Mariette
    Langers, Alexandra M. J.
    Nagengast, Fokko M.
    Vecht, Juda
    Cappel, Wouter H. de Vos Tot Nederveen
    Dekker, Evelien
    van Duijvendijk, Peter
    Vasen, Hans F. A.
    [J]. UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 2018, 6 (08) : 1215 - 1222
  • [4] Update on the Paris classification of superficial neoplastic lesions in the digestive tract
    Axon, A
    Diebold, MD
    Fujino, M
    Fujita, R
    Genta, RM
    Gonvers, JJ
    Guelrud, M
    Inoue, H
    Jung, M
    Kashida, H
    Kudo, S
    Lambert, R
    Lightdale, C
    Nakamura, T
    Neuhaus, H
    Niwa, H
    Ogoshi, K
    Rey, JF
    Riddell, R
    Sasako, M
    Shimoda, T
    Suzuki, H
    Tytgat, GNJ
    Wang, K
    Watanabe, H
    Yamakawa, T
    Yoshida, S
    [J]. ENDOSCOPY, 2005, 37 (06) : 570 - 578
  • [5] Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2019
    Bisschops, Raf
    East, James E.
    Hassan, Cesare
    Hazewinkel, Yark
    Kaminski, Michal F.
    Neumann, Helmut
    Pellise, Maria
    Antonelli, Giulio
    Bustamante Balen, Marco
    Coron, Emmanuel
    Cortas, Georges
    Iacucci, Marietta
    Yuichi, Mori
    Longcroft-Wheaton, Gaius
    Pilonis, Nastazja
    Puig, Ignasi
    van Hooft, Jeanin E.
    Dekker, Evelien
    [J]. ENDOSCOPY, 2019, 51 (12) : 1155 - 1179
  • [6] Virtual chromoendoscopy (I-SCAN) detects more polyps in patients with Lynch syndrome: a randomized controlled crossover trial
    Bisschops, Raf
    Tejpar, Sabine
    Willekens, Hilde
    De Hertogh, Gert
    Van Cutsem, Eric
    [J]. ENDOSCOPY, 2017, 49 (04) : 342 - 350
  • [7] Cancer Risks Associated With Germline Mutations in MLH1, MSH2, and MSH6 Genes in Lynch Syndrome
    Bonadona, Valerie
    Bonaiti, Bernard
    Olschwang, Sylviane
    Grandjouan, Sophie
    Huiart, Laetitia
    Longy, Michel
    Guimbaud, Rosine
    Buecher, Bruno
    Bignon, Yves-Jean
    Caron, Olivier
    Colas, Chrystelle
    Nogues, Catherine
    Lejeune-Dumoulin, Sophie
    Olivier-Faivre, Laurence
    Polycarpe-Osaer, Florence
    Nguyen, Tan Dat
    Desseigne, Francoise
    Saurin, Jean-Christophe
    Berthet, Pascaline
    Leroux, Dominique
    Duffour, Jacqueline
    Manouvrier, Sylvie
    Frebourg, Thierry
    Sobol, Hagay
    Lasset, Christine
    Bonaiti-Pellie, Catherine
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (22): : 2304 - 2310
  • [8] Real-time differentiation of adenomatous and hyperplastic diminutive colorectal polyps during analysis of unaltered videos of standard colonoscopy using a deep learning model
    Byrne, Michael F.
    Chapados, Nicolas
    Soudan, Florian
    Oertel, Clemens
    Linares Perez, Milagros
    Kelly, Raymond
    Iqbal, Nadeem
    Chandelier, Florent
    Rex, Douglas K.
    [J]. GUT, 2019, 68 (01) : 94 - 100
  • [9] Back-to-Back Comparison of Colonoscopy With Virtual Chromoendoscopy Using a Third-Generation Narrow-Band Imaging System to Chromoendoscopy With Indigo Carmine in Patients With Lynch Syndrome
    Cellier, Christophe
    Perrod, Guillaume
    Colas, Chrystelle
    Dhooge, Marion
    Saurin, Jean-Christophe
    Lecomte, Thierry
    Coron, Emmanuel
    Rahmi, Gabriel
    Savale, Camille
    Chaussade, Stanislas
    Bellanger, Jerome
    Dray, Xavier
    Benech, Nicolas
    Le Rhun, Marc
    Barbieux, Jean-Pierre
    Pereira, Helena
    Chatellier, Gilles
    Samaha, Elia
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 (10) : 1665 - 1670
  • [10] Physical activity and the risk of colorectal cancer in Lynch syndrome
    Dashti, S. Ghazaleh
    Win, Aung Ko
    Hardikar, Sheetal S.
    Glombicki, Stephen E.
    Mallenahalli, Sheila
    Thirumurthi, Selvi
    Peterson, Susan K.
    You, Y. Nancy
    Buchanan, Daniel D.
    Figueiredo, Jane C.
    Campbell, Peter T.
    Gallinger, Steven
    Newcomb, Polly A.
    Potter, John D.
    Lindor, Noralane M.
    Le Marchand, Loic
    Haile, Robert W.
    Hopper, John L.
    Jenkins, Mark A.
    Basen-Engquist, Karen M.
    Lynch, Patrick M.
    Pande, Mala
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2018, 143 (09) : 2250 - 2260