Correlation of an interleukin-4 gene polymorphism with susceptibility to severe enterovirus 71 infection in Chinese children

被引:14
作者
Li, Fei [1 ]
Liu, Xiang-ping [2 ]
Li, Ji-an [3 ]
Han, Zhen-liang [1 ]
Liu, Pei-pei [1 ]
Wang, Yuan-yuan [1 ]
Song, Long [1 ]
Chen, Zong-bo [1 ]
机构
[1] Qingdao Univ, Affiliated Hosp, Dept Pediat, Qingdao 266003, Peoples R China
[2] Qingdao Univ, Affiliated Hosp, Cent Lab Dept, Qingdao 266003, Peoples R China
[3] Shandong Univ, Qilu Childrens Hosp, Dept Infect Dis, Jinan 250022, Peoples R China
基金
美国国家科学基金会;
关键词
VIRUS-INFECTION; MOUTH-DISEASE; CLINICAL-FEATURES; NERVOUS-SYSTEM; HEPATITIS-B; ASSOCIATION; HAND; FOOT; ENCEPHALITIS; METAANALYSIS;
D O I
10.1007/s00705-015-2356-8
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Enterovirus 71 (EV71) has caused many outbreaks of diseases among children worldwide since it was first reported in 1974, but its mechanism of pathogenesis remains unclear. This study was designed to investigate the possible association of the IL-4-589C/T gene polymorphism with severity of EV71 infection in Chinese children. The IL-4 -589C/T gene polymorphism was detected in EV71-infected subjects (n = 185), including those with mild cases (n = 102) and severe cases (n = 83) as well as healthy controls (n = 234), using an improved multiplex ligation detection reaction (iMLDR) technique. The plasma levels of IL-4 and IFN-gamma were determined by enzyme-linked immunosorbent assays. The presence of the CC genotype (p = 0.022) and the C allele (OR, 2.1; 95 % CI, 1.3-3.6; p = 0.004) was significantly higher in severe cases. Furthermore, the CC genotype and C allele were also more frequently found in cases of EV71 encephalitis (p < 0.05). The plasma levels of IL-4 of the CC (7.9 +/- 1.3 pg/mL, p < 0.001) and CT genotype (6.8 +/- 2.1 pg/mL, p < 0.01) were significantly elevated compared to those of the TT genotype, but the plasma levels of IFN-gamma and the IFN-gamma/IL-4 ratio were significantly lower for the CC and CT genotypes than for the TT genotype (p < 0.05). These findings suggest that the IL-4 -589C allele could be a susceptibility factor in the development of EV71 disease in Chinese children.
引用
收藏
页码:1035 / 1042
页数:8
相关论文
共 50 条
[41]   Association of Interleukin-6-572C/G Gene Polymorphism and Serum or Cerebrospinal Fluid Interleukin-6 Level with Enterovirus 71 Encephalitis in Chinese Han Patients with Hand, Foot, and Mouth Disease [J].
Aiyun Yuan ;
Jian Li ;
Peipei Liu ;
Zongbo Chen ;
Mei Hou ;
Jinju Wang ;
Zhenliang Han .
Inflammation, 2015, 38 :728-735
[42]   Association of Interleukin-6-572C/G Gene Polymorphism and Serum or Cerebrospinal Fluid Interleukin-6 Level with Enterovirus 71 Encephalitis in Chinese Han Patients with Hand, Foot, and Mouth Disease [J].
Yuan, Aiyun ;
Li, Jian ;
Liu, Peipei ;
Chen, Zongbo ;
Hou, Mei ;
Wang, Jinju ;
Han, Zhenliang .
INFLAMMATION, 2015, 38 (02) :728-735
[43]   Interleukin-4 Gene Intron 3 VNTR Polymorphism in Type 2 Diabetes Patients with Peripheral Neuropathy [J].
Buraczynska, Monika ;
Buraczynska, Kinga ;
Zukowski, Pawel ;
Ksiazek, Andrzej .
IMMUNOLOGICAL INVESTIGATIONS, 2018, 47 (02) :146-153
[44]   The Cross-Neutralizing Activity of Enterovirus 71 Subgenotype C4 Vaccines in Healthy Chinese Infants and Children [J].
Mao, Qunying ;
Cheng, Tong ;
Zhu, Fengcai ;
Li, Jingxin ;
Wang, Yiping ;
Li, Yanping ;
Gao, Fan ;
Yang, Lisheng ;
Yao, Xin ;
Shao, Jie ;
Xia, Ningshao ;
Liang, Zhenglun ;
Wang, Junzhi .
PLOS ONE, 2013, 8 (11)
[45]   Correlation between NRAMP1 gene polymorphism and susceptibility of pulmonary tuberculosis in Chinese Tibetan population [J].
Ye, Bo ;
Zhu, Qiujing .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (06) :5974-5979
[46]   Interleukin-4-590C/T gene polymorphism in Egyptian children with acute lower respiratory infection: A multicenter study [J].
Emam, Ahmed A. ;
Shehab, Mohamed M. M. ;
Allah, Mayy A. N. ;
Elkounni, Mohamed A. ;
Abdelaal, NourEldin M. ;
Mosabah, Amira A. A. ;
Zakaria, Mervat T. ;
Sherif, Ashraf M. ;
Soliman, Mohammed M. ;
El-Kaffas, Rania M. H. ;
Abouzeid, Heba ;
Abdou, Mohammed A. ;
Abdalmonem, Nermin ;
Abdelbaset, Heba R. ;
Mohamed, Soma A. ;
Soliman, Attia A. ;
Elashkar, Shaimaa S. A. ;
Hegab, Mohamed S. ;
Khalil, Atef M. ;
Abdel-Aziz, Alsayed ;
Anany, Heba G. ;
Salah, Hossam E. ;
Abdou, Adel M. ;
Elshehawy, Naglaa A. ;
Elbasyouni, Hany A. A. ;
Hafez, Sahbaa F. M. ;
Abo-Alella, Doaa A. ;
Fawzi, Maggie M. ;
Morsi, Samar S. .
PEDIATRIC PULMONOLOGY, 2019, 54 (03) :297-302
[47]   Impact of interaction between interleukin-6 gene polymorphism and Helicobacter pylori infection on susceptibility to gastric cancer [J].
Wang, Longyue ;
Xiao, Shuaishuai ;
Zheng, Yiming ;
Gao, Zefeng ;
Fan, Fan .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2024, 33 (02) :136-140
[48]   Correlation between CYP4F2 gene rs2108622 polymorphism and susceptibility to ischemic stroke [J].
Meng, Chong ;
Wang, Juan ;
Ge, Wei-Ning ;
Tang, Shao-Can ;
Xu, Guang-Ming .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (09) :16122-16126
[49]   Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children [J].
Lu, Yapeng ;
Liu, Rui ;
Zha, Luting ;
Yuan, Shan ;
Tian, Lang ;
Chen, Jia ;
Huang, Lihua ;
Yang, Zuocheng .
DISEASE MARKERS, 2018, 2018
[50]   Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications [J].
Imani, Danyal ;
Eslami, Mohammad Masoud ;
Anani-Sarab, Gholamreza ;
Aliyu, Mansur ;
Razi, Bahman ;
Rezaei, Ramazan .
BMC MEDICAL GENETICS, 2020, 21 (01)